生长激素激发试验和胰岛素样生长因子1水平检测对生长激素缺乏症的诊断意义和思考  

Diagnostic significance and considerations of growth hormone stimulation testing and insulin-like growth factor 1 in growth hormone deficiency

作　　者：李堂[1] LI Tang(Department of Pediatric Endocrinology and Metabolism,Women and Children's Hospital,Qingdao University,Qingdao,Shandong 266000,China)

机构地区：[1]青岛大学附属妇女儿童医院儿童内分泌代谢科,山东青岛266000

出　　处：《中国当代儿科杂志》2023年第12期1193-1197,共5页Chinese Journal of Contemporary Pediatrics

摘　　要：生长激素(growth hormone,GH)/胰岛素样生长因子1(insulin growth factor-1,IGF-1)轴是下丘脑/垂体生长激素轴的重要组成部分,对儿童生长发育具有关键性作用。GH/IGF-1轴信号通路及其旁路的紊乱和异常通常在儿童时期表现为身材矮小。身材矮小的儿童通常需进行GH激发试验及IGF-1水平检测,以鉴别生长激素缺乏症(growth hormone deficiency,GHD)和其他导致生长迟缓的原因。该文对GH激发试验和IGF-1检测值进行分析与阐述,以期为临床儿童GHD的诊断提供参考。The growth hormone(GH)/insulin-like growth factor 1(IGF-1)axis is an essential component of the hypothalamic-pituitary growth hormone axis and plays a crucial role in childhood growth and development.Disruptions and abnormalities in the GH/IGF-1 signaling pathway and its pathways typically manifest as short stature in children.Children with short stature often undergo GH stimulation testing and IGF-1 level measurements to differentiate growth hormone deficiency(GHD)from other causes of growth delay.This article aims to analyze and elucidate the values of GH stimulation testing and IGF-1 measurement,providing reference for the diagnosis of GHD in children.

关 键 词：生长激素缺乏症 生长激素 胰岛素样生长因子1 生长激素激发试验 儿童 

分 类 号：R725.8[医药卫生—儿科]