ICOSL/ICOS在母胎免疫耐受中的研究进展  

Research progress of ICOSL/ICOS pathway in maternal⁃fetal immune tolerance

作　　者：梅娇琪 杨晓惠 李蒙勇威 马燕琳[1] 黄元华[1] MEI Jiao-qi;YANG Xiao-hui;LIMENG Yongwei;MA Yan-lin;HUANG Yuan-hua(Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Reseach,Department of Reproductive,The First Affiliated Hospital of Hainan Medical University,Hainan Provincial Clinical Research Center for Thalassemia,Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou Key Laboratory for Preservation of Human Genetic Resource,The First Affiliated Hospital of Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南省人类生殖与遗传重点实验室海南医学院第一附属医院生殖医学科海南省地方病(地中海贫血)临床医学研究中心海南医学院热带转化医学教育部重点实验室海南医学院第一附属医院海口市人类遗传资源宝藏重点实验室,海南海口571199

出　　处：《海南医学院学报》2023年第23期1831-1835,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金(81960283、82072880)。

摘　　要：共信号分子指细胞表面的配体与T细胞表面受体相互作用向细胞内传递刺激或抑制信号,来调节免疫反应的一类分子。共信号分子在肿瘤及自身免疫性疾病等方面发挥了重要作用。目前研究认为共信号分子也参与了母胎免疫耐受的调节,共信号分子的异常会导致母胎免疫耐受失衡从而引起复发性流产、子痫等妊娠并发症。ICOSL/ICOS是共刺激信号的配体和受体,通过参与T细胞分化、Th1、Th2细胞因子分泌调节母胎免疫耐受。因此,本文就ICOSL/ICOS结构、母胎界面中的分布及其在妊娠过程中的免疫调节进行综述,旨在为今后研究共信号分子异常引起的妊娠并发症的免疫治疗提供新思路。Co⁃signaling molecules are molecules whose ligands on the surface of cells interact with receptors on the surface of T cells to convey stimulatory or inhibitory signals to regulate immune responses.Co⁃signaling molecules play an important role in tumor and autoimmune diseases.Lately,studies have shown that co⁃signaling molecules are also involved in the regulation of maternal⁃fetal immune tolerance,and abnormalities of co⁃signaling molecules may lead to the imbalance of maternal⁃fetal immune tolerance,resulting in recurrent abortion,eclampsia and other pregnancy complications.ICOSL/ICOS is a ligand and receptor of costimulatory signals,which regulates maternal and fetal immune tolerance by participating in T cell differentiation and Th1 and Th2 cytokine secretion.Therefore,this article reviews the structure of ICOSL/ICOS,the distribution of ICOSL/ICOS at the maternal⁃fetal interface and its immune regulation during pregnancy,in order to provide new ideas for the future study of immuno⁃therapy of pregnancy complications caused by abnormal co⁃signaling molecules.

关 键 词：共刺激分子 ICOSL/ICOS 免疫耐受 TH1 TH2 

分 类 号：R714[医药卫生—妇产科学]