低剂量甲氨蝶呤致速发型超敏反应及特异质反应病例报告与机制分析  

Low Dosage Methotrxate Induced Immediate Hypersensitivity and Idiosyncrasy Reaction:Case Report and Mechanism Analysis

作　　者：林隽祺 曾晓萍 李邀俤[1] 蔡雪芬 张进华 LIN Jun-qi;ZENG Xiao-ping;LI Yao-di;CAI Xue-fen;ZHANG Jin-hua(Dept.of Pharmacy,2.Dept.of Reproductive Center,Fujian Maternity and Child Health Hospital,Gynecology and Pediatrics Clinical Medical College of Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建省妇幼保健院/福建医科大学妇儿临床医学院药剂科,福建福州350001 [2]福建省妇幼保健院/福建医科大学妇儿临床医学院生殖中心,福建福州350001

出　　处：《海峡药学》2023年第11期101-103,共3页Strait Pharmaceutical Journal

摘　　要：目的探究低剂量甲氨蝶呤中罕见的不良反应机制。方法采用诺氏评估量表评价不良反应,查阅文献回顾性分析病历特点。结果嗜酸性粒细胞增高与甲氨蝶呤可以共同影响Th2免疫反应、腺苷A 3受体激活。结论甲氨蝶呤导致速发型超敏反应和特异质反应与患者嗜酸性粒细胞增高有关。OBJECTIVE The mechanism of the rare adverse reactions induced by low dosage methotrexate was elucidated.METHODS Naranjo′s was used to assess adverse reactions and the characteristics of patient were retrospective analysed by literature review.RESULTS Eosinophilia and methotrexate could trigger Th2 immune response and adenosine receptor A 3 activation.CONCLUSION Methotrexate induced immediate hypersensitivity and idiosyncrasy reaction were associated with eosinophilia.

关 键 词：甲氨蝶呤 嗜酸性粒细胞 TH2 腺苷受体A 3 不良反应 

分 类 号：R969.3[医药卫生—药理学]