脾氨肽口服冻干粉联合注射用甲泼尼龙琥珀酸钠治疗支气管肺炎患儿的效果  

Effects of Spleen aminopeptide oral lyophilized powder combined with Methylprednisolone sodium succinate for injection on children with bronchopneumonia

作　　者：吴单单 WU Dandan(Department of Pediatrics of General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000 Henan,China)

机构地区：[1]平煤神马医疗集团总医院儿科,河南平顶山467000

出　　处：《中国民康医学》2023年第22期83-86,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察脾氨肽口服冻干粉联合注射用甲泼尼龙琥珀酸钠治疗支气管肺炎患儿的效果。方法:回顾性分析2021年1月至2023年4月该院收治的154例支气管肺炎患儿的临床资料,按照治疗方法不同将其分为对照组和观察组各77例。两组均进行常规治疗,在此基础上,对照组予以注射用甲泼尼龙琥珀酸钠治疗,观察组在对照组基础上联合脾氨肽口服冻干粉治疗,两组均持续治疗7 d。比较两组临床疗效、临床指标(咳嗽咳痰消失时间、体温恢复时间和肺部湿啰音消失时间)水平、治疗前后肺功能指标[潮气量(TV)、最大呼气流量(PEF)、呼吸频率(RR)、用力肺活量(FVC)]水平、免疫指标[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.21%(71/77),高于对照组的80.52%(62/77),差异有统计学意义(P<0.05);观察组咳嗽咳痰消失时间、体温恢复时间、肺部湿啰音消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组TV、PEF、FVC水平均高于对照组,RR水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组IgA、IgM、IgG水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脾氨肽口服冻干粉联合注射用甲泼尼龙琥珀酸钠治疗支气管肺炎患儿可提高治疗总有效率和免疫指标水平,改善肺功能指标水平,降低临床指标水平,效果优于单纯注射用甲泼尼龙琥珀酸钠治疗。Objective:To observe effects of Spleen aminopeptide oral lyophilized powder combined with Methylprednisolone sodium succinate for injection on children with bronchopneumonia.Methods:The clinical data of 154 children with bronchopneumonia admitted to this hospital from January 2021 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,77 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Methylprednisolone sodium succinate for injection,while the observation group was treated with Spleen Aminopeptide oral lyophilized powder on the basis of that of the control group.Both groups were treated for 7 d.The clinical efficacy,the clinical index levels(cough and expectoration disappearance time,body temperature recovery time and lung moist rale disappearance time),the lung function index levels[tidal volume(TV),peak expiratory flow(PEF),respiratory rate(RR),forced vital capacity(FVC)],the immune index levels[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 92.21%(71/77),which was higher than 80.52%(62/77)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of cough and expectoration,the body temperature recovery time and the lung moist rale disappearance time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TV,PEF and FVC in the observation group were higher than those in the control group,the RR level was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IgA,IgM and IgG in the observation group were higher than those in the control group,and the differen

关 键 词：支气管肺炎 脾氨肽口服冻干粉 注射用甲泼尼龙琥珀酸钠 肺功能 免疫功能 不良反应 

分 类 号：R725.6[医药卫生—儿科]