肉牛羊消化道寄生蠕虫耐药性研究进展  

Research Progress on Anthelmintic Resistance of Gastrointestinal Parasite in Beef and Sheep

作　　者：李梦玥 贾旭晨 洪炀 朱怡平 段云芳 庹世友 王子璇 李靖[1,4] LI Meng-yue;JIA Xu-chen;HONG Yang;ZHU Yi-ping;DUAN Yun-fang;TUO Shi-you;WANG Zi-xuan;LI Jing(National Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Key Laboratory of Parasite Pathogen and Vector Biology,National Health Commission,WHO Collaborating Center for Tropical Diseases,National International Joint Research Center for Tropical Diseases,National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(National Center for Tropical Diseases Research),Shanghai 200025,China;Tibet Autonomous Region Emergency Management Department,Lhasa 850011,China;Research Center for Animal Husbandry in Kashgar City(Research Center for Angus),Kashgar 844000,China)

机构地区：[1]中国农业大学动物医学院兽医公共卫生安全全国重点实验室,北京海淀100193 [2]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海卢湾200025 [3]西藏自治区应急管理厅,西藏拉萨850011 [4]喀什地区畜牧研究中心(安格斯牛研究中心),新疆喀什844000

出　　处：《中国兽医杂志》2023年第11期85-89,共5页Chinese Journal of Veterinary Medicine

基　　金：新疆维吾尔自治区重点研发计划项目(2022B02056-2)。

摘　　要：由于长期使用种类有限的体内驱虫药物,世界范围内肉牛羊消化道寄生蠕虫耐药性问题日益严重。本文概述了国内外肉牛羊消化道寄生蠕虫耐药性的现状及其产生机制,从基因突变、生存压力和药物使用等因素,分析了耐药基因频率升高的原因;总结了粪便虫卵减数试验、体外检测试验和分子检测等检测方法的优缺点,为科研和生产实践中的寄生蠕虫耐药性检测提供了参考;提出了科学用药建立“避难所”、研发新型驱虫药物、加强饲养管理等缓解耐药性形成的可行性措施。本文旨在引起肉牛羊产业对消化道寄生蠕虫耐药性的重视,并为精准高效进行耐药性检测和逐步减缓肉牛羊消化道寄生蠕虫耐药性提供依据,从而提升肉牛羊科学健康养殖水平,进一步推动肉牛羊产业高质量发展。The escalating problem of gastrointestinal parasite drug resistance in beef and sheep worldwide is attributed to the prolonged use of a limited range of anthelmintic drugs.This article reviews the current status and mechanisms of gastrointestinal parasite anthelmintic resistance in beef and sheep,analyzing factors such as gene mutations,survival pressure,and drug usage that contribute to the increasing frequency of resistant genes.The advantages and disadvantages of various detection methods,including fecal egg count reduction tests,in vitro assays,and molecular detection,are summarized to provide valuable references for anthelmintic resistance detection in research and practical applications.Feasible measures to alleviate the emergence of anthelmintic resistance are proposed,such as rational drug use to establish"refuges",development of novel anthelmintic drugs,and improved feeding management.The aim of this article is to raise awareness of gastrointestinal parasite anthelmintic resistance in the beef and sheep industry,providing a basis for precise and efficient anthelmintic resistance detection and mitigation,and ultimately promoting the scientific and healthy breeding practices of beef and sheep to enhance the high-quality development of the industry.

关 键 词：消化道寄生虫 驱虫药物 耐药性 肉牛 肉羊 

分 类 号：S855.9[农业科学—临床兽医学]