活血逐瘀汤联合常规西药治疗老年冠心病心绞痛的效果及对血液流变学指标的影响  

Effect of Huoxue Zhuyu Decoction Combined with Conventional Western Medicine on Angina Pectoris of Elderly Coronary Heart Disease and Its Influence on Hemorheology

作　　者：侯佳颀 HOU Jiaqi(Xuzhou City Hospital of TCM,Jiangsu Province,Xuzhou 221000,China)

机构地区：[1]江苏省徐州市中医院,江苏徐州221000

出　　处：《中国医学创新》2023年第32期80-84,共5页Medical Innovation of China

摘　　要：目的:探讨活血逐瘀汤联合常规西药治疗老年冠心病心绞痛的效果及对血液流变学指标的影响。方法:选择2021年1月—2022年1月于徐州市中医院诊治的老年冠心病心绞痛患者86例,使用随机数字表法分为观察组(43例)及对照组(43例)。对照组接受常规西药治疗,观察组在对照组基础上加用活血逐瘀汤,于治疗前后对比两组心绞痛发作情况,血液流变学、心功能、血脂、氧化应激指标及治疗总有效率。结果:治疗前,两组心绞痛发作时间、发作次数及硝酸甘油用量、血浆黏度、全血黏度、纤维蛋白原、红细胞聚集指数、红细胞压积比较,差异均无统计学意义(P>0.05);治疗后,两组心绞痛发作时间均较治疗前缩短,两组上述其他各项指标均较治疗前下降,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)比较,差异均无统计学意义(P>0.05);治疗后,两组LVEF均较治疗前升高,观察组高于对照组,LVESV及LVEDV均较治疗前下降,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)比较,差异均无统计学意义(P>0.05);治疗后,两组上述指标均较治疗前上升,观察组均高于对照组,差异均有统计学意义(P<0.05)。观察组的治疗总有效率(95.35%)高于对照组(81.40%),差异有统计学意义(P<0.05)。结论:活血逐瘀汤联合常规西药可显著缩短老年冠心病心绞痛患者心绞痛的发作时间,调节血液流变学及血脂指标,减轻氧化应激反应,改善心功能,效果优异。Objective:To investigate the effect of Huoxue Zhuyu Decoction combined with conventional western medicine on angina pectoris in elderly patients with coronary heart disease and its influence on hemorheology.Method:From January 2021 to January 2022,a total of 86 elderly patients with angina pectoris due to coronary atherosclerotic heart disease who were diagnosed and treated in Xuzhou City Hospital of TCM were selected and divided into the observation group(43 cases)and the control group(43 cases)according to the random number table method.The control group was treated with conventional western medicine,and the observation group was treated with Huoxue Zhuyu Decoction on the basis of the control group.Before and after the treatment,the episodes of angina pectoris,hemorheology,cardiac function,blood lipids,oxidative stress index and total effective rate were compared between the two groups.Result:Before treatment,there were no statistically significant differences in the time of angina pectoris attack,the number of attacks,the dosage of Nitroglycerin,plasma viscosity,whole blood viscosity,fibrinogen,erythrocyte aggregation index,and hematocrit between the two groups(P>0.05);the time of angina pectoris attack in the two groups were shorter than those before treatment,and the other indicators in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,the left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV)of two groups were compared,the differences were not statistically significant(P>0.05);after treatment,the LVEF of the two groups were higher than those before treatment,the observation group was higher than that of the control group,and the LVESV and LVEDV were lower than those before treatment,and the observation group were lower than those of the control group,the differences were statistical

关 键 词：老年冠心病心绞痛 活血逐瘀汤 血液流变学 心功能 血脂 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]