卵泡输出率对多囊卵巢综合征不孕症患者妊娠结局的影响  

The Impact of Follicle Output Rate on Pregnancy Outcomes in Infertility Patients With Polycystic Ovary Syndrome

作　　者：曾月萍 张明霞 ZENG Yueping;ZHANG Mingxia(Department of Reproductive Medicine,the Second Affiliated Hospital of Fujian Medical University,Quanzhou Fujian 362000,China)

机构地区：[1]福建医科大学附属第二医院生殖医学科,福建泉州362000

出　　处：《中国卫生标准管理》2023年第22期29-32,共4页China Health Standard Management

摘　　要：目的探讨不同卵泡输出率(follicular output rate,FORT)水平对多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者妊娠相关指标及结局的影响。方法选取2018年6月—2021年6月福建医科大学附属第二医院收治的249例PCOS不孕症患者作为研究对象,以65%作为FORT分组条件,将患者分为高FORT组(n=125)和低FORT组(n=124)。比较两组患者的相关临床资料、妊娠相关指标及妊娠结局。结果高FORT组注射日卵泡刺激素(follicle stimulating hormone,FSH)水平低于低FORT组,差异有统计学意义(P<0.05);而雌二醇(estradiol,E_(2))、孕酮(progesterone,P)水平高于低FORT组,差异有统计学意义(P<0.05)。高FORT组注射日子宫内膜厚度为(12.53±1.21)mm,而低FORT组为(11.17±1.18)mm,差异有统计学意义(t=8.978,P<0.001)。高FORT组降调天数为(14.55±1.44)d,低FORT组为(16.20±1.63)d,差异有统计学意义(t=8.467,P<0.001)。高FORT组优质胚胎率和临床妊娠率分别为(70.36±6.62)%和(60.15±5.90)%,而低FORT组分别为(64.54±5.38)%和(55.87±5.56)%,差异有统计学意义(P<0.001)。结论PCOS不孕症患者高FORT状态可以提高窦卵泡对外源性卵泡刺激素的反应性,改善妊娠条件,提高优质胚胎率及临床妊娠率。Objective To explore the impact of different levels of follicular output rate(FORT)on pregnancy related indicators and outcomes in infertility-patients with polycystic ovary syndrome(PCOS).Methods A total of 249 infertility-patients with PCOS admitted to the Second Affiliated Hospital of Fujian Medical University from June 2018 to June 2021 were selected as the study subjects,and they were divided into a high FORT group(n=125)and a low FORT group(n=124)with FORT value of 65%.The relevant clinical data,pregnancy related indicators,and pregnancy outcomes of two groups were compared.Results The levels of follicle stimulating hormone(FSH)on the day of injection in the high FORT group were lower than those in the low FORT group,with statistical significance(P<0.05).While the levels of estradiol(E_(2))and progesterone(P)were higher than those in the low FORT group,with statistical significance(P<0.05).The endometrial thickness on the day of injection in the high FORT group was(12.53±1.21)mm,while that in the low FORT group was(11.17±1.18)mm,with a statistically significant difference(t=8.978,P<0.001).The number of days of downregulation in the high FORT group was(14.55±1.44)d,while in the low FORT group was(16.20±1.63)d,with a statistically significant difference(t=8.467,P<0.001).The high-quality embryo rate and clinical pregnancy rate of the high FORT group were(70.36±6.62)%and(60.15±5.90)%,respectively,while the low FORT group was(64.54±5.38)%and(55.87±5.56)%,with statistically significant differences(P<0.001).Conclusion High FORT status in infertility-patients with PCOS can improve the responsiveness of sinus follicles to exogenous follicle stimulating hormone,improve pregnancy conditions,and increase the rate of high-quality embryos and clinical pregnancy.

关 键 词：多囊卵巢综合征 卵泡输出率 不孕症 辅助生殖治疗 激素水平 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]