腹腔镜手术联合西药对慢性盆腔炎急性发作患者IL-1β、SIgA、MCP-1水平的影响  

Effects of laparoscopic surgery combined with Western medicine on levels of IL⁃1β,SIgAand MCP⁃1 in patients with acute onset of chronic pelvic inflammatory disease

作　　者：李华[1] 张丹 徐洪 杜晓丽[1] 高建宏[1] 郭雪娇 张东明 高金荣[1] 贾西贝 LI Hua;ZHANG Dan;XU Hong;DU Xiaoi;GAO Jianhong;GUO Xuejiao;ZHANG Dongming;GAO Jinrong;JIA Xibei(Department of Gynecology,Langfang People's Hospital,Langfang,Hebei,China,065000;Hebei Provincial Key Laboratory of Organ Fibrosis,Tangshan,Hebei,China,063210;Department of Gynecology,Gu'an Hospital of Traditional Chinese Medicine,Langfang,Hebei,China,065500;61267 Army Health Team,Tongzhou District,Beijing,China,101146;Department of Clinical Studies,Kanazawa University,Ishikawa Prefecture,Japan,920-0000)

机构地区：[1]廊坊市人民医院妇科,河北廊坊065000 [2]河北省器官纤维化重点实验室,河北唐山063210 [3]固安县中医院妇科,河北廊坊065500 [4]61267部队卫生队,北京101146 [5]日本金泽大学临床系,日本石川县920-0000

出　　处：《分子诊断与治疗杂志》2023年第10期1724-1727,1732,共5页Journal of Molecular Diagnostics and Therapy

基　　金：廊坊市卫生局项目(2019013020)。

摘　　要：目的 探讨慢性盆腔炎急性发作患者应用腹腔镜手术与西药结合治疗对白细胞介素-1β(IL-1β)、宫颈分泌型IgA(SIgA)、单核细胞趋化蛋白-1(MCP-1)水平的影响。方法 将廊坊市人民医院2019年7月至2022年7月收治的116例慢性盆腔炎急性发作患者分组,按照简单随机数字表法分为对照组(n=58)和观察组(n=58),对照组采用西药治疗,观察组采用腹腔镜手术与西药结合治疗。评估治疗前、治疗1周后两组的临床疗效、恢复指标,并比较两组患者治疗前后的IL-1β、SIgA、MCP-1水平、血液流变学水平以及不良反应发生率与复发率。结果 观察组的总有效率高于对照组,差异有统计学意义(χ^(2)=8.593,P<0.05)。观察组的体温恢复时间、血象恢复时间、住院时间均短于对照组,差异有统计学意义(t=13.420、3.430、3.140,P<0.05)。与治疗前相比,治疗1周后两组的IL-1β、SIgA、MCP-1水平均降低,且观察组低于对照组,差异有统计学意义(t=3.196、18.461、15.330,P<0.05)。与治疗前相比,治疗1周后两组的全血高切黏度、全血低切黏度均降低,且观察组低于对照组,差异有统计学意义(t=3.090、3.582,P<0.05)。观察组的不良反应发生率、3个月后随访复发率低于对照组,差异有统计学意义(χ^(2)=4.245、4.336,P<0.05)。结论 腹腔镜手术与西药结合治疗疗效显著,可改善患者的IL-1β、SIgA、MCP-1水平及血液流变学,且其不良反应发生率与复发率降低。Objective To investigate the effects of laparoscopic surgery combined with western medicine on the levels of interleukin-1β(IL-1β),cervical secretory IgA(SIgA)and monocyte chemotactic protein-1(MCP-1)in patients with acute onset of chronic pelvic inflammatory disease.Methods A total of 116 patients with acute onset of chronic pelvic inflammatory disease admitted to Langfang People's Hospital from July 2019 to July 2022 were divided into the control group(n=58)and the observation group(n=58)according to a simple random number table method.The control group was treated with western medicine,and the observation group was treated with laparoscopic surgery combined with Western medicine.The clinical efficacy and recovery indexes of the two groups were evaluated before and after 1 week of treatment,and the levels of IL-1β,SIgA,MCP-1,hemorheology,incidence of adverse reactions and recurrence were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(X^(2)=8.593,P<0.05).The temperature recovery time,blood image recovery time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(t=13.420,3.430,3.140,P<0.05).After 1 week of treatment,the levels of IL-1β,SIgA and MCP-1 in both groups were decreased,and the observation group was lower than the control group,with statistical significance(t=3.196,18.461,15.330,P<0.05).Compared with before treatment,whole blood high tangential viscosity and whole blood low tangential viscosity decreased in both groups after 1 week of treatment,and the observation group was lower than the control group,the difference was statistically significant(t=3.090,3.582,P<0.05).The incidence and recurrence of adverse reactions in the observation group were lower than those in the control group,and the difference was statistically significant(X^(2)=4.245,4.336,P<0.05).Conclusion Laparoscopic surger

关 键 词：慢性盆腔炎急性发作 腹腔镜手术 西药 IL-1Β SIGA MCP-1 

分 类 号：R711.33[医药卫生—妇产科学]