血清IFN-γ、IL-1β联合PCT检测在卵巢囊肿蒂扭转中的临床应用  

Clinical application of serum IFN⁃γ,IL⁃1βcombined with PCT detection in torsion of ovarian cyst pedicle

作　　者：罗滢[1] 樊雷[2] 张慧力[2] LUO Ying;FAN Lei;ZHANG Huii(Department of Obstetrics and Gynecology,731 Hospital of China Aerospace Science and Industry Corporation,Beijing,China,100074;Department of Intervention,731 Hospital of China Aerospace Science and Industry Corporation,Beijing,China,100074)

机构地区：[1]中国航天科工集团七三一医院妇产科,北京100074 [2]中国航天科工集团七三一医院介入科,北京100074

出　　处：《分子诊断与治疗杂志》2023年第10期1741-1744,共4页Journal of Molecular Diagnostics and Therapy

基　　金：北京妇幼保健院中青年学科骨干培养专项(FCYY201903)。

摘　　要：目的 分析血清干扰素-γ(IFN-γ)、白介素1β(IL-1β)联合降钙素原(PCT)检测在卵巢囊肿蒂扭转中的临床应用。方法 选取2019年8月至2022年12月中国航天科工集团七三一医院收治的158例疑似卵巢囊肿蒂扭转患者为研究对象,经术中探查发现158例疑似卵巢囊肿蒂扭转患者中有83例确诊为卵巢囊肿蒂扭转。分析卵巢囊肿蒂扭转者治疗前后血清IFN-γ、IL-1β、PCT水平,计算血清IFN-γ、IL-1β、PCT单独及联合检测在诊断卵巢囊肿蒂扭转中的阳性预测值、阴性预测值、一致性以及诊断效能。结果经过治疗后,卵巢囊肿蒂扭转患者血清IFN-γ、IL-1β、PCT水平均明显下降,差异有统计学意义(P<0.05);IFN-γ+IL-1β+PCT的阳性预测值、阴性预测值、灵敏度、特异度及准确率分别为98.79%、97.33%、97.62%、98.65%、98.10%,均高于IFN-γ、IL-1β、PCT单独检测;血清IFN-γ、IL-1β、PCT单独以及联合诊断卵巢囊肿蒂扭转与术中探查结果的一致性Kappa值分别为0.511、0.623、0.724、0.976。结论 血清IFN-γ、IL-1β、PCT联合检查卵巢囊肿蒂扭转的诊断效果强于单独检测,血清IFN-γ、IL-1β、PCT联合检查与临床卵巢囊肿蒂扭转的术中探查结果的一致性高,为卵巢囊肿蒂扭转的诊断以及预后提供了更为准确的依据。Objective To analyze the clinical application of serum interferon-γ(IFN-γ),interleukin-1β(IL-1β)combined with procalcitonin(PCT)in torsion of ovarian cyst.Methods 158 cases of suspected torsion of ovarian cyst pedicle admitted to our hospital from August 2019 to December 2022 were selected as the study objects,intraoperative exploration revealed that 83 cases of suspected torsion of ovarian cyst pedicle were confirmed as torsion of ovarian cyst pedicle.Serum IFN-γ,IL-1βand PCT levels were analyzed in patients with ovarian cyst pedicle torsion before and after treatment.Serum IFN-γ、IL-1β、the positive predictive value,negative predictive value,consistency,and diagnostic efficacy of PCT alone and in combination in the diagnosis of ovarian cyst pedicle torsion were calculated.Results After treatment,serum levels of IFN-γ,IL-1βand PCT in patients with torsion of ovarian cyst pedicle were significantly decreased,and the difference was statistically significant(P<0.05).The positive predictive value,negative predictive value,sensitivity,specificity,and accuracy of IFN-γ+IL-1β+PCT were 98.79%,97.33%,97.62%,98.65%and 98.10%,respectively,which were higher than IFN-γ,IL-1βand PCT alone;the Kappa values of serum IFN-γ,IL-1βand PCT for single and combined diagnosis of pedicle torsion of ovarian cyst were 0.511,0.623,0.724 and 0.976,respectively.Conclusion The diagnostic effect of serum IFN-γ,IL-1βand PCT combined detection of ovarian cyst pedicle torsion is stronger than that of single detection,and the results of serum IFN-γ,IL-1βand PCT combined detection are in high agreement with the intraoperative exploration results of clinical ovarian cyst pedicle torsion,which provides a more accurate basis for the diagnosis and prognosis of ovarian cyst pedicle torsion.

关 键 词：IFN-Γ IL-1Β PCT检测 卵巢囊肿蒂扭转 

分 类 号：R711.75[医药卫生—妇产科学]