血清PA、SAA、IL-6检测在小儿急性上呼吸道感染诊断中的应用  

Application of serum PA,SAA combined with IL⁃6 detection in diagnosis of acute upper respiratory tract infection in children

作　　者：颜玉丹 李晓琴 郑小丹 杨晓玲[1] 龙涛[1] 龙升毅 YAN Yudan;LI Xiaoqin;ZHENG Xiaodan;YANG Xiaoing;LONG Tao;LONG Shengyi(Department of Pediatrics,the First People's Hospital of Longquanyi District,Chengdu,Sichuan,China,610100;Department of Pediatrics,the Affiliated Hospital of Southwest Medical University(Sichuan Birth Defects Clinical Medical Research Center),Luzhou,Sichuan,China,646000;Department of Traditional Chinese Medicine,the First People's Hospital of Longquanyi District,Chengdu,Sichuan,China,610100;Department of Pediatrics,Zhenping County Hospital,Ankang,Shaanxi,China,725600)

机构地区：[1]成都市龙泉驿区第一人民医院儿科,四川成都610100 [2]西南医科大学附属医院(四川省出生缺陷临床医学研究中心)儿科,四川泸州646000 [3]成都市龙泉驿区第一人民医院中医科,四川成都610100 [4]镇坪县医院儿科,陕西安康725600

出　　处：《分子诊断与治疗杂志》2023年第10期1808-1811,共4页Journal of Molecular Diagnostics and Therapy

基　　金：四川省科技计划基金资助项目(2022YFS0731)。

摘　　要：目的 分析血清前白蛋白(PA)、淀粉样蛋白A(SAA)联合白介素(IL-6)检测在小儿急性上呼吸道感染诊断中的应用价值。方法 选取2020年3月至2023年1月成都市龙泉驿区第一人民医院收治的急性上呼吸道感染患儿98例(观察组)作为研究对象,选取同期进行健康体检的70名儿童为对照组。对比两组研究对象以及观察组不同病情严重程度血清PA、SAA、IL-6水平的差异,采用Logistic回归分析影响小儿急性上呼吸道感染发生的危险因素,绘制ROC曲线分析血清PA、SAA及IL-6单独检测及联合检测小儿急性上呼吸道感染的诊断效果。结果 观察组SAA、IL-6水平均高于对照组,PA水平低于对照组,差异有统计学意义(P<0.05);观察组不同病情严重程度血清PA水平:轻度>中度>重度,血清SAA水平:重度>中度>轻度,血清IL-6水平:重度>中度>轻度,差异均有统计学意义(P<0.05);Logistic回归分析发现,血清PA、SAA及IL-6为影响小儿急性上呼吸道感染发生的独立影响因素(P<0.05);血清PA、SAA、IL-6联合检测的AUC为0.827,高于血清PA、SAA、IL-6单独检测(P<0.05)。结论 小儿急性上呼吸道感染患儿血清PA、SAA及IL-6水平均处于异常状态,监测上述指标有助于为临床小儿急性上呼吸道感染早期诊断、治疗提供有效的依据。Objective To analyze the diagnostic value of serum Prealbumin(PA),Serums mamyloid A(SAA)and Interleukin 6(IL-6)detection in diagnosis of children with acute upper respiratory tract infection.Methods 98 children with acute upper respiratory tract infection admitted to our hospital from March 2020 to January 2023(observation group)were selected as the study objects,and 70 children who underwent routine check-up during the same period were selected as the control group.The levels of serum PA,SAA and IL-6 were compared between the two groups and the observation group,and the risk factors affecting the occurrence of acute upper respiratory tract infection in children were analyzed by Logistic regression,and the ROC curve was drawn to analyze the diagnostic effect of serum PA,SAA and IL-6 alone and combined detection of acute upper respiratory tract infection in children.Results The levels of SAA and IL-6 in the observation group were higher than those in the control group,and the levels of PA in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Serum PA level:mild>moderate>severe,serum SAA level:severe>moderate>mild,serum IL-6 level:severe>moderate>mild,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that serum PA,SAA and IL-6 were independent factors affecting the occurrence of acute upper respiratory tract infection in children(P<0.05).The AUC of serum PA,SAA and IL-6 combined detection was 0.827,which was higher than that of serum PA,SAA and IL-6 alone(P<0.05).Conclusion The levels of serum PA,SAA and IL-6 in children with acute upper respiratory tract infection are abnormal;monitoring the above indicators is helpful to provide an effective basis for early diagnosis and treatment of acute upper respiratory tract infection in children.

关 键 词：PA SAA IL-6 小儿急性上呼吸道感染 

分 类 号：R725.6[医药卫生—儿科]