轮状病毒肠炎致心肌损伤的影响因素及其与血清IgA、IgG、hs-CRP的关联  

The influence factors of myocardial injury caused by rotavirus enteritis and its association with serum IgA,IgG and hs⁃CRP

作　　者：刘虎 郭长江 田常营 LIU Hu;GUO Changjiang;TIAN Changying(Department of Pediatrics,Funan County Peoples Hospital,Fuyang,Anhui,China,236300)

机构地区：[1]阜南县人民医院儿二科,安徽阜阳236300

出　　处：《分子诊断与治疗杂志》2023年第11期1882-1885,1894,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委科研项目(AHWJ2021b005)。

摘　　要：目的 分析研究轮状病毒肠炎致心肌损伤的影响因素及其与血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、超敏C反应蛋白(hs-CRP)的关联。方法 选取2020年1月1日至2022年12月31日阜南县人民医院儿科收治的121例轮状病毒肠炎并发心肌损伤患儿,将其命名为心肌损伤组,另选同期收治的121例轮状病毒肠炎无心肌损伤患儿作为对照组。收集患儿的相关临床资料,采用单因素、多因素Logistic回归分析轮状病毒肠炎并发心肌损伤的影响因素;采用Pearson相关系数分析轮状病毒肠炎并发心肌损伤患儿血清IgA、IgG、hs-CRP与心肌肌钙蛋白Ⅰ(cTnⅠ)的相关性,并采用ROC曲线分析血清IgA、IgG与hs-CRP水平对轮状病毒肠炎并发心肌损伤的预测价值。结果 单因素分析结果显示,呕吐、脱水、腹泻次数、血清IgA、IgG及hs-CRP水平均是轮状病毒肠炎并发心肌损伤患儿的影响因素(P<0.05);多因素Logistic回归分析显示,呕吐(OR=2.094)、脱水(OR=2.040)、腹泻次数>10次/d(OR=1.992)IgA水平降低(OR=1.982)、IgG水平降低(OR=1.966)和hs-CRP水平升高(OR=2.186)均是轮状病毒肠炎并发心肌损伤的独立危险因素(P<0.05);Pearson相关性分析显示,轮状病毒肠炎并发心肌损伤患儿血清IgA、IgG与cTnⅠ呈负相关,hs-CRP与cTnⅠ呈正相关(均P<0.05);ROC曲线分析显示血清IgA、IgG、hs-CRP水平及联合检测的曲线下面积(AUC)分别为0.818、0.755、0.798、0.921,联合检测优于单一检测(P<0.05)。结论 儿童轮状病毒肠炎并发心肌损伤与多种因素相关,血清IgA、IgG、hs-CRP水平可能成为儿童轮状病毒肠炎并发心肌损伤的辅助诊断指标。Objective To analyze the influencing factors of myocardial injury caused by rotavirus enteritis and their association with the expression of serum immunoglobulin A(IgA),immunoglobulin G(IgG)and hypersensitive C-reactive protein(hs-CRP).Methods A total of 121 children with rotavirus enter-itis complicated with myocardial injury admitted to the Department of Pediatrics of Funan County Peoples Hos-pital from January 1,2020 to December 31,2022 were selected as the myocardial injury group,and 121 chil-dren with rotavirus enteritis without myocardial injury admitted during the same period were selected as the control group.The relevant clinical data of the children were collected,and the influencing factors of rotavirus enteritis complicated with myocardial injury were analyzed by univariate and multivariate logistic regression.Pearson correlation coefficient was used to analyze the correlation between serum IgA,IgG,hs-CRP and Car-diac troponin I(cTnI)in children with rotavirus enteritis complicated with myocardial injury,and the ROC curve was used to analyze the predictive value of serum IgA,IgG and hs-CRP levels in rotavirus enteritis com-plicated with myocardial injury.Results Univariate analysis showed that vomiting,dehydration,frequency of diarrhea,serum IgA,IgG and hs-CRP levels were all influential factors in children with rotavirus enteritis complicated with myocardial injury(P<0.05).Multivariate logistic regression analysis showed that vomiting(OR=2.094),dehydration(OR=2.040),diarrhea frequency>10 times/day(OR=1.992),IgA level decreased(OR=1.982),IgG level decreased(OR=1.966)and the increase of hs-CRP level(OR=2.186)was an inde-pendent risk factor for rotavirus enteritis complicated with myocardial injury(P<0.05).Pearson correlation analysis showed that serum IgA and IgG were negatively correlated with cTnI in children with rotavirus enteri-tis complicated with myocardial injury,while hs-CRP was positively correlated with cTnI(P<0.05).The ROC curve analysis showed that the serum IgA,IgG and hs-CRP levels and t

关 键 词：轮状病毒肠炎 心肌损伤 免疫球蛋白A 免疫球蛋白G 超敏C反应蛋白 

分 类 号：R725.1[医药卫生—儿科]