敌草快中毒机制与预后研究进展  

Research progress on the mechanism and prognosis of rapid poisoning of

作　　者：吕明秀 杜宇 LV Ming-xiu;DU Yu(West China School of Public Health,Sichuan University/West China Fourth Hospital,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院急诊科,四川成都610041 [2]四川大学华西-协和陈志潜卫生健康研究院卫生应急管理研究中心,四川成都610041

出　　处：《现代预防医学》2023年第23期4273-4277,共5页Modern Preventive Medicine

基　　金：四川省科技计划重点研发项目(2023YFS0205)。

摘　　要：敌草快(diquat,DQ)是继百草枯(paraquat,PQ)后又一使用广、危害大的除草剂,由于缺乏特效解毒剂,病死率极高。目前毒理机制尚未完全阐明,普遍认为是氧化应激引起级联反应,进而造成各组织器官受损导致多器官功能障碍。患者早期表现多样,由于缺乏标准化或准确的评估系统,治疗时机选择难以精准把握,如何早期实施精准的个体化医疗降低死亡率和致残率仍是医学界难题。鉴于此,本综述总结了急性DQ中毒的发病机制和预后评估现状,为改进临床治疗决策和预后评估提供参考。Diquat(DQ)is another widely used and harmful herbicide in addition to paraquat(PQ).Due to the lack of specific antidote,the case fatality rate is extremely high.At present,the toxicological mechanism has not been fully elucidated,and it is generally believed that oxidative stress causes cascade reactions,resulting in multiple organ dysfunction caused by damage to various tissues and organs.The early manifestations of DQ poisoning vary,and it is difficult to accurately capture the timing of treatment due to the lack of standardized or accurate evaluation system.How to implement accurate individualized medical treatment to reduce mortality and disability rate remains a medical challenge.Therefore,this review summarizes the pathogenesis and prognosis evaluation of acute DQ poisoning to provide reference for improving clinical treatment,decision-making,and prognosis evaluation.

关 键 词：敌草快 中毒机制 临床表现 预后 

分 类 号：R595.4[医药卫生—内科学]