贵州省农村女性初育年龄与老年期轻度认知功能损害的关系  

Relationship between the age at first birth and mild cognitive impairment in the elderly rural women in Guizhou Province

作　　者：陈晓玲 屈芳 杨敬源[1] 陈明燕 熊燕 薛维娜 龙茜 杨星 CHEN Xiao-ling;QU Fang;YANG Jing-yuan;CHEN Ming-yan;XIONG Yan;XUE Wei-na;LONG Xi;YANG Xing(School of Public Health,Guizhou Medical University,Guiyang,Guizhou 561113,China;不详)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113 [2]攀枝花市疾病预防控制中心慢性非传染病病防治科 [3]贵州医科大学医药卫生管理学院,贵州贵阳558099

出　　处：《现代预防医学》2023年第23期4296-4302,共7页Modern Preventive Medicine

基　　金：国家自然科学基金(81760613);贵州医科大学国家自然科学基金培育项目(20NSP079)。

摘　　要：目的探讨贵州省农村女性初育年龄与其老年期轻度认知功能损害的关系,为改善农村老年女性认知功能现状提供科学依据。方法于2019年7—8月采用多阶段整群抽样方法抽取贵州省2个县(区)的5个乡镇共1653名老年人,以其中952名农村老年女性作为研究对象进行问卷调查和体格检查,采用简易智能状态量表(MMSE)进行认知功能检测,运用SPSS 26.0软件进行单因素χ^(2)和秩和检验,比较老年女性不同人口学特征和初育年龄与其老年期认知功能的差异,采用多因素非条件logistic回归分析初育年龄对轻度认知功能损害的影响。结果研究对象共检出轻度认知功能损害380例,总检出率为39.92%(380/952);单因素分析结果显示,不同年龄段(χ^(2)=45.074,P<0.001)、民族(χ^(2)=15.979,P<0.001)、受教育程度(χ^(2)=10.394,P<0.05)、BMI(χ^(2)=18.961,P<0.001)、每天体育锻炼时间(χ^(2)=9.199,P<0.05)、婚姻状态(χ^(2)=13.150,P<0.001)和吸烟(χ^(2)=4.318,P<0.05)的老年女性轻度认知功能损害检出率的差异均有统计学意义;初育年龄>23岁的贵州省农村老年女性在年龄≥70岁人群中的检出率高于初育年龄≤23岁者,且MMSE总分(Z=-1.961,P<0.05)、即刻记忆力(Z=-2.108,P<0.05)和延时回忆(Z=-3.047,P<0.05)得分均低于初育年龄≤23岁者,差异具有统计学意义。年龄≥70岁组多因素非条件logistic回归分析结果显示,初育年龄>23岁(OR=1.537,95%CI:1.053~2.244)是轻度认知功能损害的危险因素。结论贵州省农村老年女性轻度认知功能损害检出率较高,初育年龄可能是贵州省农村70岁及以上老年女性轻度认知功能损害的病因线索,其因果关联还有待于进一步深入研究。Objective To explore the relationship between the age at first birth and mild cognitive impairment in the elderly rural women in Guizhou Province,so as to provide scientific basis for improving the current situation of their cognitive function.Methods A total of 1653 elderly people from 5 townships in 2 counties(districts)of Guizhou Province were selected by multi-stage cluster sampling from July to August,2019.Among them,952 rural elderly women were investigated by questionnaire and physical examination,and the cognitive function was tested by Mini-Mental State Examination(MMSE).SPSS 26.0 software was used for univariateχ^(2) or rank sum test,to compare the difference of the cognitive function in old age among rural womon with dfifferent dermgrophic characteristics and ages at first birth,and multivariate Logistic regression was used to analyze the influence of age at first birth on mild cognitive impairment.Results A total of 380 cases of mild cognitive impairment were detected,with a total detection rate of 39.92%(380/952).The results of univariate analysis showed that the differences in the rates of mild cognitive impairment among elderly rural women were statistically significant in terms of the following factors:age groups(χ^(2)=45.074,P<0.001),ethnic groups(χ^(2)=15.979,P<0.001),education level(χ^(2)=10.394,P<0.05),BMI(χ^(2)=18.961,P<0.001),daily exercise time(χ^(2)=9.199,P<0.05),marital status(χ^(2)=13.150,P<0.001),and smoking(χ^(2)=4.318,P<0.05).In the age group of≥70 years old,the detection rate of mild cognitive impairment was higher in those aged above 23 years than those aged≤23 years at first birth,and the total scores of MMSE(Z=-1.961,P<0.05),immediate memory(Z=-2.108,P<0.05),and delayed memory(Z=-3.047,P<0.05)were significantly lower than the latter.The results of multivariate unconditional Logistic regression analysis in the age group≥70 years old showed that the age at first birth>23 years old(OR=1.537,95%CI:1.053-2.244)was a risk factor for mild cognitive impairment.Conclusion The

关 键 词：农村 女性 初育年龄 轻度认知功能损害 

分 类 号：C924.2[社会学—人口学] C913.68