不对称傅-克反应在构建手性3-取代吲哚中的研究进展  

Recent Progress in the Construction of Chiral 3-Substituted Indoles by Asymmetric Friedel-Crafts Reactions

作　　者：刘甜甜 段新红[1] Liu Tiantian;Duan Xinhong(College of Science,Beijing Forestry University,Beijing 100083)

机构地区：[1]北京林业大学理学院,北京100083

出　　处：《有机化学》2023年第11期3695-3712,共18页Chinese Journal of Organic Chemistry

基　　金：北京林业大学“卓越实验师”培育专项基金(No.20210902)资助项目。

摘　　要：由于手性3-取代吲哚化合物是许多具有生物活性天然产物和药物分子的核心骨架,其合成方法的研究就格外令人注目.尤其是近二十年来,利用手性金属配合物和有机小分子催化剂实现吲哚的C(3)位不对称傅-克烷基化反应已成为有机界广泛研究的热点.按照促进不对称傅-克烷基化反应的手性催化剂进行分类,就近年来其在3-取代吲哚化合物合成中的应用加以综述,并对今后的发展方向进行了展望.Chiral C(3)-functionalized indoles have received much attention as strategic building blocks for the synthesis of many natural products and bioactive compounds.Particularly in the past twenty years,application of chiral metal complexes and small-molecule organocatalysts for the asymmetric Friedel-Crafts C(3)-alkylations of indoles has become a hot topic in the organic field.Applications of asymmetric Friedel-Crafts reactions in the synthesis of C(3)-substituted indoles are reviewed according to the catalysts that promoting reaction.Moreover,future perspectives are also presented.

关 键 词：手性催化剂 不对称傅-克烷基化 手性3-取代吲哚 手性诱导 

分 类 号：O626[理学—有机化学]