1,4-吡啶硫内鎓盐在有机合成中的研究与应用  

Research and Application of Pyridinium 1,4-Zwitterionic Thiolates in Organic Synthesis

作　　者：侯学会 李议慧 张庆玲 刘俊桃 陈亚静 Xuehui Hou;Yihui Li;Qingling Zhang;Juntao Liu;Yajing Chen(Faculty of Science,Henan University of Animal Husbandry and Economy,Zhengzhou 450046;School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]河南牧业经济学院理学部,郑州450046 [2]郑州大学药学院,郑州450001

出　　处：《有机化学》2023年第11期3844-3860,共17页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22201267);河南省科技攻关(Nos.232102111051,232102110019,232102320289)资助项目。

摘　　要：1,4-吡啶硫内鎓盐是一类重要的氮硫杂合成子,其中的吡啶片段既可以作为离去基团,也可以作为亲电反应位点参与反应,构建多种类型的氮硫杂骨架.因此,近年来1,4-吡啶硫内鎓盐在含氮、含硫杂环化合物的合成应用中受到了极大的关注.基于此,系统综述了1,4-吡啶硫内鎓盐在两种反应模式([3+m]和[5+m]环合反应)下构建氮硫杂环的研究进展,总结了其在环合反应及杂环化学中的应用,并对该领域的研究前景进行了展望.Pyridinium 1,4-zwitterionic thiolates are important sulfur-and nitrogen-containing synthons,in which the pyridine fragments can act as leaving groups,but also as electrophilic sites,constructing various types of sulfur-and nitrogen-hetero-cycles.Hence,pyridinium 1,4-zwitterionic thiolates have attracted much attention on the synthesis for N-containing and S-containing heterocyclic compounds in recent years.The progress of pyridinium 1,4-zwitterionic thiolates participated annulation via[3+m]and[5+m]modes is reviewed,their applications on constructing N-and S-heterocyclic rings are summarized,and their future prospects are discussed.

关 键 词：1 4-吡啶硫内鎓盐 环合反应 含氮杂环 含硫杂环 

分 类 号：O626[理学—有机化学]