钴催化芳基烯烃氧烷基化反应:快速获得α-烷基取代苯乙酮衍生物  

Cobalt-Catalyzed Oxyalkylation Reaction of Styrenes:Rapid Access toα-Alkyl Substituted Acetophenone Derivatives

作　　者：周鹏 朱伟明 张建涛 肖朵朵 郭祥峰 刘卫兵 Zhou Penga;Zhu Weiming;Zhang Jiantao;Xiao Duoduo;Guo Xiangfeng;Liu Weibing(College of Chemistry,Guangdong University of Petrochemical Technology,Maoming,Guangdong 525000;b Maoming Green Chemical Industry Research Institute,Maoming,Guangdong 525099)

机构地区：[1]广东石油化工学院化学学院,广东茂名525000 [2]茂名绿色化工研究院,广东茂名525099

出　　处：《有机化学》2023年第11期3939-3944,共6页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Sailing Plan of Maoming Green Chemical Industry Research Institute(No.MMGCIRI-2022YFJH-Y-037);the Science and Technology Planning Project of Maoming City(No.2022031);the Special Projects in Key Fields of Ordinary Universities of Guangdong Province(No.2020ZDZX2054)。

摘　　要：烷基芳基酮是化学和生物学中一类有价值的化合物,被广泛应用于制药、香料、染料、农药、功能材料以及有机合成行业.发展了钴催化芳基烯烃与叔丁基过氧化氢(TBHP)以及环醚的氧烷基化反应.该方法适用于各种带有吸电子基团或给电子基团的烯烃底物,并且以中等产率得到α-烷基取代苯乙酮衍生物.该方案具有广泛的底物适用范围及灵活性,在温和条件下即可快速构建一系列增值的苯乙酮衍生物.Alkyl aryl ketones are a class of valuable compounds in chemistry and biology,which are widely used in the pharmaceutical,spice,dye,pesticide,functional materials,and organic synthesis industries.A cobalt-catalyzed oxyalkylation reaction of aryl olefin with tert-butyl hydroperoxide(TBHP)and cyclic ethers was developed.Various substrates with electron-withdrawing or electron-donating groups were tolerated in this protocol to provide theα-alkyl substituted acetophenones in moderate yields.The present protocol features broad substrate scope,and flexibility,allowing rapid assembly of a series of value-added acetophenone derivatives under mild conditions with good reaction efficacy.

关 键 词：烷基芳基酮 钴催化 氧烷基化 苯乙酮衍生物 

分 类 号：O621.251[理学—有机化学]