碘促进N,N-二甲基乙酰胺(DMA)与胺的转酰胺反应  

Iodine-Promoted Transamidation of N,N-Dimethylacetamide(DMA)with Amines

作　　者：马豪杰 周风院 苏凡文 韩波[1] 李然 张玉琦[1] 王记江[1] Ma Haojie;Zhou Fengyuan;Su Fanwen;Han Bo;Li Ran;Zhang Yuqi;Wang Jijiang(Key Laboratory of New Energy&New Functional Materials,Shaanxi Key Laboratory of Chemical Reaction Engineering,College of Chemistry and Chemical Engineering,Yan'an University,Yan'an,Shaanxi 716000)

机构地区：[1]延安大学化学与化工学院、陕西省化学反应工程重点实验室、新能源与新功能材料重点实验室,陕西延安716000

出　　处：《有机化学》2023年第11期3960-3965,共6页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.31701679);the Young Talent Fund of Association for Science and Technology in Shaanxi(No.20220609);the Open Sharing Platform for Scientific and Technological Resources of Shaanxi Province(No.2021PT-004);the Yan’an Science and Technology Planning Project(No.2022SLSFGG-005);the Young Talent Fund of Association for Science and Technology in Yanan(No.8);the Yan’an University Training Program of Innovation and Entrepreneurship for Undergraduates(No.D2021032);the Yan’an University Industry-University-Research Co-operative Cultivation Project(No.CXY202102);the Youth Innovation Team Project of Shaanxi Provincial Education Department(No.23JP193);the Youth Innovation Team of Shaanxi Universities。

摘　　要：报道了一种新颖、简便的N,N-二甲基乙酰胺(DMA)与胺的转酰胺反应,用于合成乙酰胺类化合物,产率适中至优良.廉价的碘可以有效地促进该反应,且反应条件简单、官能团耐受性良好、无需预官能团化,具有一定的实用性,可广泛用于乙酰胺药物和生物活性分子的合成.A novel and convenient transamidation of N,N-dimethylacetamide(DMA)with amines for the synthesis of acetamides with moderate to excellent yields is reported.Low-cost I2 is used as efficient promoter for this transformation.Furthermore,the reaction has simple conditions,good functional group tolerance,substrates without prefunctionalization,and practicality,which can be widely used in the synthesis of acetamide drugs and biologically active molecules.

关 键 词：碘 N-乙酰化 转酰胺 N N-二甲基乙酰胺 乙酰胺 

分 类 号：O621.25[理学—有机化学]