硅基羧酸在有机合成中的应用进展  

Application Progress of Silyl Carboxylic Acid in Organic Synthesis

作　　者：郭广青 练仲 Guo Guangqing;Lian Zhong(State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041;West China School of Pharmacy,Sichuan University,Chengdu 610041)

机构地区：[1]四川大学华西医院生物治疗国家重点实验室,成都610041 [2]四川大学华西药学院,成都610041

出　　处：《有机化学》2023年第10期3580-3589,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21901168);四川省科技计(No.2021YJ0395);四川大学华西医院1.3.5优秀学科建设资助项目。

摘　　要：羧酸在有机体基本生命过程中起着非常重要的作用,同时在有机合成化学领域也是一种功能强大的合成砌块.因此,无论是天然存在还是人工合成的羧酸都已经从多个方面被广泛研究.硅基羧酸,作为羧酸的类似物,因其独特的理化性质和潜在的反应性吸引了化学家们的关注.综述了硅基羧酸在插羰偶联反应、硅自由基反应以及酯化反应中的应用.硅基羧酸作为硅自由基前体。Carboxylic acids play important roles in basic life processes within organisms,and are powerful building blocks in the field of organic synthesis.Therefore,natural or artificial carboxylic acids have been studied from a variety of viewpoints.Silyl carboxylic acids,as analogues of carboxylic acids,are highly attractive due to their unique physical and chemical properties as well as their potential reactivity.The applications of silyl carboxylic acids in the carbonyl coupling reactions,silyl radical reactions and esterification are summarized.

关 键 词：硅基羧酸 一氧化碳 羰基化反应 硅基自由基前体 

分 类 号：O621.3[理学—有机化学]