铜催化双炔膦氧化物硅质子化反应合成β-硅基取代的乙烯基膦氧化物  

Regioselective Synthesis ofβ-Silyl-Substituted Vinylphosphine Oxides via Copper-Catalyzed Protosilylation of Dialkynylphosphine Oxides

作　　者：陈志远 杨梦维 徐建林 徐允河 ChenZhiyuan;YangMengwei;XuJianlin;XuYunhe(Department of Chemistry,University of Science and Technology of China,Hefei 230026)

机构地区：[1]中国科学技术大学化学与材料科学学院,合肥230026

出　　处：《有机化学》2023年第10期3598-3607,共10页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.21871240);the Fundamental Research Funds for the Central Universities(No.WK2060000017)。

摘　　要：报道了铜催化双炔基膦氧化物单侧硅质子化合成β-硅基取代乙烯基膦氧化物的反应.各种(杂)芳基和烷基取代的二炔膦氧化物能够以中等和较高的产率和较高的化学选择性得到相应的目标产物.产物中未反应的炔基可以被进一步衍生为其它官能团.A copper-catalyzed mono-lateral protosilylation of dialkynylphosphine oxides for the synthesis ofβ-silyl substituted vinylphosphine oxides is described.Various(hetero)aryl and alkyl-substituted diynes afforded the corresponding products in moderate and high yields with high chemoselectivity.An alternative alkynyl functional group of products could also be further derived.

关 键 词：铜催化剂 硅质子化反应 膦氧化合物 β-硅基取代化合物 

分 类 号：O627.51[理学—有机化学]