芳基乙烯基硅烷与芳基卤代物的Hiyama偶联反应  

Hiyama Cross-Coupling Reaction of Aryl Vinylsilanes and Aryl Halides

作　　者：马伟源 戴惠芳[2] 亢少林 张天麟 舒兴中 Ma Wei-Yuan;Dai Huifang;Kang Shaolin;Zhang Tianlin;Shu Xing-Zhong(State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000;School of Pharmacy,Fudan University,Shanghai 201203)

机构地区：[1]兰州大学功能有机分子化学国家重点实验室,兰州730000 [2]复旦大学药学院,上海201203

出　　处：《有机化学》2023年第10期3614-3622,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071084,22271127);中央高校基本科研业务费专项资金(No.lzujbky-2022-ey01)资助项目.

摘　　要：Hiyama偶联反应已经发展成为一种构筑C—C键的常用方法,尤其是在芳基-芳基和芳基-烯基偶联反应领域.Hiyama偶联反应通常需要使用R—SiF_(3)、R—Si(OMe)_(3)等活性高但稳定性差的有机硅试剂,发展基于稳定硅烷的Hiyama偶联反应是该领域重要的研究方向.报道了一类钯催化芳基乙烯基硅烷和芳基卤代物的交叉偶联反应,利用芳基乙烯基硅烷实现芳基化反应.反应具有较好的官能团兼容性,为制备二芳基类化合物提供了一种简便高效的途径.The Hiyama coupling reaction has emerged as a wildly used method for the construction of C—C bonds,especially in the fields of aryl-aryl and aryl-alkenyl coupling reactions.In general,this protocol highly relies on reactive but unstable silicon reagents such as R—SiF_(3)and R—Si(OMe)_(3).The development of Hiyama coupling reaction involving stable organosilanes is in high demand.In this manuscript,a palladium-catalyzed cross-coupling reaction of aryl vinylsilanes and aryl halides is reported,leading to the formation of Ar—Ar bonds.The reaction has shown good functional group compatibility and offered convenient access to biaryl compounds.

关 键 词：Hiyama反应 偶联反应 芳基乙烯基硅烷 芳基化 二芳基化合物 

分 类 号：O621.25[理学—有机化学]