葛氏分型与射血分数保留的心力衰竭  

GE's phenotyping and heart failure with preserved ejection fraction

作　　者：孔令秋[1] 葛均波 KONG Lingqiu;GE Junbo(Department of Cardiology,Hospital of Chengdu University of TCM,Chengdu Sichuan 610072;Department of Cardiology,Zhongshan Hospital Affiliated to Fudan University,Shanghai Municipal Institute of Cardiovascular Disease,Shanghai 200032,China)

机构地区：[1]成都中医药大学附属医院心血管科,四川成都610072 [2]复旦大学附属中山医院心内科,上海市心血管病研究所,上海200032

出　　处：《实用心电学杂志》2023年第6期453-456,共4页Journal of Practical Electrocardiology

基　　金：国家自然科学基金青年基金资助项目(86103615)。

摘　　要：有别于其他类型的心力衰竭(简称心衰),传统药物及治疗方法在射血分数保留的心衰(heart failure with preserved ejection fraction,HFpEF)患者中往往缺乏确切疗效。究其原因,可能与这类患者的病因异质性较大、病理生理学通路不一致有关。葛氏分型是一种基于病因学的新型分类方法,不仅有助于对病理生理学机制相似的HFpEF患者进行分组,而且还有助于为不同类型的心衰患者制定合适的诊治方案、预后评估及管理措施,有望成为未来针对此类患者进行临床研究设计的重要参考。Unlike other types of heart failure(HF),the efficacy of traditional medication and therapies are usually not reliable in patients with HF with preserved ejection fraction(HFpEF).It may be attributed to obviously heterogeneous etiologies and inconsistent pathophysiological pathways among such patients.GE's phenotyping is a novel etiology-oriented classification method.It not only facilitates grouping HFpEF patients with similar pathophysiological mechanisms,but also contributes to making appropriate diagnosis and treatment plans,and taking prognosis assessment and management measures for different types of HF patients.In the future,GE's phenotyping is expected to be an important reference for clinical study design for these patients.

关 键 词：心力衰竭 左心室射血分数 健康相关生活质量 死亡率 预测指标 

分 类 号：R541.6[医药卫生—心血管疾病]