贵阳市男男性行为者艾滋病病毒暴露前药物预防使用及相关因素研究  

Usage of pre-exposure prophylaxis and its related factors among men who have sex with men in Guiyang City

作　　者：包愿 佘敏[2] 王大朋[1] 张欐 李劲[2] 祝继[2] 杨琴[2] 黄燕瑶 徐素芹 马璐[1,2] BAO Yuan;SHE Min;WANG Dapeng;ZHANG Li;LI Jin;ZHU Ji;YANG Qin;HUANG Yanyao;XU Suqin;MA Lu(School of Public Health,Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,Guiyang 550025,Guizhou,China;Guiyang Center for Disease Control and Prevention,Guiyang 550018,Guizhou,China)

机构地区：[1]贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室,贵阳550025 [2]贵阳市疾病预防控制中心,贵阳550018

出　　处：《中国艾滋病性病》2023年第11期1177-1183,共7页Chinese Journal of Aids & STD

基　　金：贵州省卫生健康委科学技术基金项目(gz⁃wkj2023-480)。

摘　　要：目的了解贵阳市MSM对HIV PrEP使用情况,并对其影响因素进行分析,为今后在贵阳市推广PrEP提供参考。方法通过非概率抽样方法招募18岁以上、HIV检测结果为阴性及发生过男男性行为的研究对象填写PrEP调查问卷。了解服药人群和非服药人群的相关情况,并采用χ2/Fisher检验和多因素Logistic回归模型对影响因素进行分析。结果问卷共调查252人,服药者111人,未服药者141人,服药者以按需服药(99.1%,110/111),线上取药(75.7%,84/111)为主。多因素分析显示,在本地居住2年及以下(OR=5.812,95%CI:2.454~13.760),在校学生(OR=4.198,95%CI:1.673~10.537),最近一次肛交时使用安全套(OR=3.487,95%CI:1.536~7.917),愿意每月花500元以下用于PrEP(OR=4.017,95%CI:1.327~12.160)等是使用PrEP的促进因素,而性伴HIV感染状况不详(OR=0.229,95%CI:0.092~0.570)和近一年曾被诊断过性病(OR=0.037,95%CI:0.003~0.488)是使用PrEP的抑制因素。结论本研究调查的MSM服药以按需服药和线上取药为主,同时影响该人群PrEP使用的因素较多,应针对其使用情况和影响因素,制定相关防控策略和措施,促进MSM使用PrEP。Objective To understand the use of HIV pre-exposure prophylaxis(PrEP)and its associated factors among men who have sex with men(MSM)in Guiyang,in order to provide a reference for promoting PrEP usage in Guiyang City in the future.Methods A non-probability sampling method was used to recruit participants who were over 18 years old,HIV-negative and had sex with men to complete the PrEP questionnaire.χ2/Fisher test and multivariate logistic regression model were used to analyze the influencing factors.Results A total of 252 individuals were surveyed by questionnaire,of whom 111 cases were taking PrEP and 141 cases were not.Medication was mainly obtained on demand(99.1%,110/111)and online(75.7%,84/111).Multivariate analysis showed that local residents for 2 years or less(OR=5.812,95%CI:2.454-13.760),being school students(OR=4.198,95%CI:1.673-10.537),using condoms during the last anal sex(OR=3.487,95%CI:1.536-7.917),and being willing to spend less than 500 yuan per month for PrEP(OR=4.017,95%CI:1.327-12.160)were promoting factors for PrEP use.In contrast,not knowing the HIV infection status of sexual partners(OR=0.229,95%CI:0.092-0.570)and having been diagnosed with a sexually transmitted disease(STD)in the last year(OR=0.037,95%CI:0.003-0.488)were the barrier for PrEP use.Conclusions Medication intake among MSM participating in this study is mainly based on on-demand and online.There were many factors influencing PrEP use among MSM.It is necessary to develop relevant prevention and control strategies and measures,so as to promote the use of PrEP among MSM.

关 键 词：男男性行为者 艾滋病病毒 暴露前预防 影响因素 

分 类 号：R373.9[医药卫生—病原生物学]