云南省HIV-1分子流行病学研究及实践进展  

Research and practice progress on molecular epidemiology of HIV-1 in Yunnan Province

作　　者：张肖 董莉娟[2] 陈会超[2] 马艳玲[2] 陈敏[2] ZHANG Xiao;DONG Lijuan;CHEN Huichao;MA Yanling;CHEN Min(School of Public Health,Kunming Medical University,Yunnan 650500,Kunming,China;Institute for AIDS/STDs Control and Prevention,Yunnan Provincial Center for Disease Control and Prevention,Yunnan 650022,Kunming,China)

机构地区：[1]昆明医科大学公共卫生学院,昆明650500 [2]云南省疾病预防控制中心性病艾滋病防制所,昆明650022

出　　处：《中国艾滋病性病》2023年第11期1271-1275,共5页Chinese Journal of Aids & STD

基　　金：云南省科技人才和平台计划项目(2019HB053);“十三五”国家科技重大专项(2018ZX10715006)。

摘　　要：HIV分子流行病学研究在HIV基因分型、病毒重组鉴定、传播源追踪、传播链和高风险传播者发现等方面发挥着重要作用。云南省是中国艾滋病最早流行的地区,随着时间的推移,云南省HIV的传播范围及传播方式发生了极大转变。多种HIV毒株在云南省的流行成为病毒重组变异的基础,使云南省HIV-1基因型呈现出明显的地域性、复杂性和多样性,也给云南省艾滋病防治工作带来挑战。本文对云南省近30年HIV-1基因亚型特征及变异趋势进行回顾和分析,总结流行规律,为艾滋病防治提供参考依据。HIV molecular epidemiological researches play an important role in HIV genotyping,virus recombination identification,transmission source tracing,and discoveries for transmission chain and high-risk transmitters.Yunnan Province is the earliest area of the AIDS epidemic in China.Over time,the scope and mode of HIV/AIDS transmission in Yunnan Province have changed greatly.The prevalence of multiple HIV strains in Yunnan Province has become the basis for viral recombination and variation,which makes the HIV-1 genotype in Yunnan Province show a distinct regionalism,complexity,and diversity,and also challenges the AIDS prevention and control work in Yunnan Province.This paper reviews and analyzes the characteristics and variation trends of HIV-1 subtypes in Yunnan Province in the past 30 years,summarizes the epidemic pattern,and provides a reference for HIV/AIDS prevention and control.

关 键 词：1型艾滋病病毒 分子流行病学 基因亚型 重组病毒 

分 类 号：R512.91[医药卫生—内科学]