Emerging open-channel droplet arrays for biosensing  

作　　者：Yongchao Song Lirong Wang Tailin Xu Guangyao Zhang Xueji Zhang 

机构地区：[1]School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen 518060,China [2]Intelligent Wearable Engineering Research Center of Qingdao,Research Center for Intelligent and Wearable Technology,College of Textiles and Clothing,State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University,Qingdao 266071,China

出　　处：《National Science Review》2023年第10期167-181,共15页国家科学评论（英文版）

基　　金：supported by the Joint Fund of the Ministry of Education of China for Equipment Pre-Research(8091B0206);the Shenzhen Stability Support Plan(20200806163622001);the Shenzhen Overseas Talent Program and the Shenzhen Key Laboratory for Nano-Biosensing Technology(ZDSYS20210112161400001)。

摘　　要：Open-channel droplet arrays have attracted much attention in the fields of biochemical analysis,biofluid monitoring,biomarker recognition and cell interactions,as they have advantages with regard to miniaturization,parallelization,high-throughput,simplicity and accessibility.Such droplet arrays not only improve the sensitivity and accuracy of a biosensor,but also do not require sophisticated equipment or tedious processes,showing great potential in next-generation miniaturized sensing platforms.This review summarizes typical examples of open-channel micro droplet arrays and focuses on diversified biosensing integrated with multiple signal-output approaches(fluorescence,colorimetric,surface-enhanced Raman scattering(SERS),electrochemical,etc.).The limitations and development prospects of open-channel droplet arrays in biosensing are also discussed with regard to the increasing demand for biosensors.

关 键 词：open-channel droplet wettable pattern mini-pillar platform liquid marbles multiple biosensing 

分 类 号：TN492[电子电信—微电子学与固体电子学] TP212.3[自动化与计算机技术—检测技术与自动化装置]