生物相容透皮给药微针治疗浅表肿瘤  

Biocompatible Transdermal Microneedles for Superficial Tumor Therapy

作　　者：石清霞 尹婷 郑明彬[2,3] 蔡林涛 SHI Qing-Xia;YIN Ting;ZHENG Ming-Bin;CAI Lin-Tao(School of Pharmacy,Guangdong Medical University,Dongguan 523808,China;CAS Key of Laboratory of Health Informatics,Guangdong Key Laboratory of Nanomedicine,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,Shenzhen 518112,China)

机构地区：[1]广东医科大学药学院,东莞523808 [2]中国科学院深圳先进技术研究院,中国科学院健康信息学重点实验室,广东省纳米医药重点实验室,深圳518055 [3]深圳市第三人民医院(南方科技大学第二附属医院),国家感染性疾病临床医学研究中心,肝病研究所,深圳518112

出　　处：《生物化学与生物物理进展》2023年第11期2636-2648,共13页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81901864);深圳市科技计划项目(JCYJ20210324115611032);广东省自然科学基金(2022A1515011337);广东省普通高校重点领域专项(2022ZDZX2022);广东省大学生科技创新专项资金(pdjh2022b0227);2022年广东医科大学博士研究经费;广东省高校特色创新项目(2021KTSCX036);广东省中医局中药研究项目(20221206)资助。

摘　　要：复杂的肿瘤微环境导致抗肿瘤药物在肿瘤组织内递送效率低下,严重阻碍了药物对浅表肿瘤的治疗效果。生物相容透皮给药微针凭借较高的机械强度,刺穿皮肤角质层,将微针内的药物递送至浅表肿瘤组织内,提高生物利用度,改善静脉注射、口服给药的肝肾毒性等问题。本文介绍了生物相容透皮给药微针的设计及其在癌症化疗、光动力治疗、光热治疗、免疫治疗、基因治疗等领域的研究进展,对浅表肿瘤的微创、局部递药和精准、高效治疗具有重要指导意义。The complex tumor microenvironment leads to the inefficient intra-tumor delivery of antitumor drugs severely restrict the therapeutic effect of drugs on superficial tumors.At present,the main treatment methods for superficial tumors are surgical resection,chemotherapy,radiotherapy.These therapies can destroy tumor tissue or inhibit the growth of cancer cells in the short term,but the long-term treatment results are not satisfactory.With the research of anti-tumor treatment,chemotherapy,photodynamic therapy(PDT),photothermal therapy(PTT),gene therapy and immunotherapy and other new combined treatment strategies have the advantages of good therapeutic effect,small invasion,and low toxic and side effects,and have shown great potential for the treatment of superficial tumors.In order to achieve good therapeutic efficacy,it is necessary to effectively deliver therapeutic drugs(photosensitizers,photothermal agents,chemotherapeutic drugs,etc.)to the tumor site to exert anti-tumor effect.Based on the major drawbacks of the traditional administration strategy,such as low bioavailability of oral administration,pain,poor targeting,and systemic toxicity caused by subcutaneous/intravenous administration.It is important to develop safe and effective anticancer drug delivery strategies to promote novel cancer therapies.The transdermal delivery system(TDS)can deliver the drug through the stratum corneum of skin into the dermis and through capillaries into the bloodstream,effectively overcoming low bioavailability associated with oral administration.In addition,subcutaneous/intravenous administration often causes pain sensation defects,TDS can significantly improving patient medication compliance.However,due to the presence of a cuticle barrier on the skin that hinders drug penetration,there is a significant reduction in drug delivery efficiency,limiting its further application.The emergence of biocompatible transdermal microneedles presents a promising solution for enhancing drug penetration in TDS.These microneedles are compose

关 键 词：生物相容微针 药物递送 透皮给药 控制释放 浅表肿瘤 

分 类 号：Q5[生物学—生物化学] R3[医药卫生—基础医学] R9