猪瘟病毒免疫逃避机制以及猪瘟的防控进展  

Recent developments in immune evasion mechanisms of classical swine fever virus and prevention and control of classical swine fever

作　　者：邹宏 罗干 李玲 夏应菊 徐璐[1] 赵俊杰[1] 张乾义[1] ZOU Hong;LUO Gan;LI Ling;XIA Yingju;XU Lu;ZHAO Junjie;ZHANG Qianyi(National/OIE Reference Laboratory for Classical Swine Fever,China Institute of Veterinary Drugs Control,Beijing 100081,China;Wanzhou Center for Animal Disease Prevention and Control,Chongqing 404100,China)

机构地区：[1]中国兽医药品监察所国家/OIE猪瘟参考实验室,北京100081 [2]重庆市万州区动物疫病预防控制中心,重庆404100

出　　处：《中国兽医学报》2023年第9期1977-1982,共6页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(31872484)。

摘　　要：猪瘟(classical swine fever,CSF)是由猪瘟病毒(classical swine fever virus,CSFV)引起的被OIE列为必须报告的一种烈性传染病。CSFV作为一种单链RNA包膜病毒,在适应外界环境压力的过程中,不断发生重组和进化,已经演变出一套完美的免疫逃避策略。为了解CSFV逃避机制和防控的最新进展,现将对CSFV抑制干扰素产生、CSFV调控细胞凋亡、CSFV调控细胞自噬、CSFV调控细胞焦亡与炎症反应、CSFV逃避适应性免疫应答和CSF的防控方面进行概述,以期为CSFV致病机制的研究和CSF防控提供理论帮助。Classical swine fever(CSF),caused by classical swine fever virus(CSFV),is a virulent infectious disease that is classified as a notifiable disease by OIE.As a single-stranded RNA enveloped virus,CSFV has evolved a series of strategies to encounter the host immune defense and the response to external environmental stresses.To understand the recent developments of immune evasion mechanisms of CSFV and prevention and control of CSF,the aspects of CSFV on inhibition of interferon production,apoptosis,autophagy,cell death,inflammatory response,evasion of adaptive immune response,and preventive aspects were reviewed,which provides theoretical basis for the study of CSFV pathogenesis and CSF prevention and control.

关 键 词：CSFV 免疫逃避 CSF防控 

分 类 号：S855.3[农业科学—临床兽医学]