内源性气体信号分子NO在动物流产过程中的作用及其研究进展  

Role and research progress of endogenous gas signaling molecule NO in animal abortion

作　　者：崔晓 张勇[1] CUI Xiao;ZHANG Yong(Gansu Province Key Laboratory for Animal Reproductive Physiology and Reproductive Regulation,College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]甘肃农业大学动物医学学院甘肃省动物生殖生理及繁殖调控重点实验室,甘肃兰州730070

出　　处：《中国兽医学报》2023年第11期2396-2402,共7页Chinese Journal of Veterinary Science

基　　金：甘肃省动物生殖生理及繁殖调控重点实验室资助项目(20JR10RA563);动物繁殖疾病防控协同创新团队资助项目(2018C-15)。

摘　　要：内源性一氧化氮(nitric oxide,NO)由机体内一氧化氮合酶(nitric oxide synthase,NOS)诱导产生,流产动物子宫和胎盘组织内均有NOS的表达。内源性NO能参与维持动物正常妊娠,但其过量表达也易引起动物妊娠病变,甚至导致流产。目前,内源性NO与动物妊娠和流产的确切关系尚不明确。对内源性NO在动物妊娠、流产过程中的作用及其研究进展进行综述,旨在能为动物流产的防制提供参考依据。Endogenous nitric oxide(NO)is induced by nitric oxide synthase(NOS)in the organism.NOS is expressed in the uterus and placenta of aborted animals.Endogenous NO can not only participate in the maintenance of normal pregnancy in animals,but its over-expression can also easily cause pathological changes in animal pregnancy and even lead to abortion.At present,the exact relationship between endogenous NO and animal pregnancy and abortion is unclear.This article reviews the role and research progress of endogenous NO in animal pregnancy and abortion in order to provide reference for the prevention and control of animal abortion.

关 键 词：一氧化氮 动物流产 免疫调节 抗炎 血管舒张 细胞凋亡 

分 类 号：S852.2[农业科学—基础兽医学] S857.2[农业科学—兽医学]