不同抗菌药物用药方案治疗小儿支气管肺炎的效果比较  

Comparison of effects of different antimicrobial regimens in the treatment of bronchopneumonia in children

作　　者：杨艳 何洁[1] 朱虹 YANG Yan;HE Jie;ZHU Hong(Hohhot First Hospital,Hohhot 010030,China)

机构地区：[1]呼和浩特市第一医院,010030

出　　处：《中国现代药物应用》2023年第22期53-56,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究不同抗菌药物用药方案对小儿支气管肺炎的治疗效果。方法118例小儿支气管肺炎患儿,根据抗菌药物用药方案的不同分为Ⅰ组(38例)、Ⅱ组(41例)、Ⅲ组(39例)。Ⅰ组经阿奇霉素+头孢噻肟治疗,Ⅱ组经阿奇霉素+阿莫西林克拉维酸钾治疗,Ⅲ组经阿奇霉素+阿莫西林钠舒巴坦钠治疗。对比三组治疗效果、不良反应发生率及康复指标。结果三组患儿的治疗效果对比,差异无统计学意义(P>0.05)。Ⅰ组患儿的不良反应发生率为7.89%(3/38),Ⅱ组患儿的不良反应发生率为9.76%(4/41),Ⅲ组患儿的不良反应发生率为7.69%(3/39)。三组患儿的不良反应发生率对比,差异无统计学意义(P>0.05)。三组患儿的发热时间、咳嗽咳痰时间、憋喘时间、住院时间对比,差异无统计学意义(P>0.05)。结论针对小儿支气管肺炎患儿,采用阿奇霉素分别联合头孢噻肟、阿莫西林克拉维酸钾、阿莫西林钠舒巴坦钠进行治疗效果无明显差异,均能达到可靠的治疗效果,可以根据不同患儿的实际情况选择抗菌药物用药方案。Objective To study the effects of different antimicrobial regimens in the treatment of bronchopneumonia in children.Methods A total of 118 children with bronchopneumonia were divided into groupⅠ(38 cases),groupⅡ(41 cases)and groupⅢ(39 cases)according to the different regimen of antibiotics.GroupⅠwas treated with azithromycin+cefotaxime,groupⅡwas treated with azithromycin+amoxicillin and clavulanate potassium,and groupⅢwas treated with azithromycin+amoxicillin sodium and sulbactam sodium.The therapeutic effect,incidence of adverse reactions and rehabilitation indexes of the three groups were compared.Results There was no statistically significant difference in therapeutic effect among the three groups(P>0.05).The incidence of adverse reactions was 7.89%(3/38)in groupⅠ,9.76%(4/41)in groupⅡand 7.69%(3/39)in groupⅢ.There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).There was no statistically significant difference in fever duration,cough and expectoration time,duration of asthma and hospital stay among the three groups(P>0.05).Conclusion For children with bronchopneumonia,azithromycin combined with cefotaxime,amoxicillin and clavulanate potassium,amoxicillin sodium and sulbactam sodium have no significant difference in therapeutic effect,and all can achieve reliable therapeutic effect.Antibacterial drug regimens can be selected according to the actual situation of children.

关 键 词：阿奇霉素 头孢噻肟 阿莫西林克拉维酸钾 阿莫西林钠舒巴坦钠 支气管肺炎 

分 类 号：R725.6[医药卫生—儿科]