保和丸联合阿莫西林克拉维酸钾治疗小儿肠系膜淋巴结炎的疗效观察  

Efficacy observation of Baohe pills combined with amoxicillin and clavulanate potassium in the treatment of children with mesenteric lymphadenitis

作　　者：方吉琴 成莹 吴慧 FANG Ji-qin;CHENG Ying;WU Hui(Department of Pediatrics,Ganxian District People's Hospital,Ganzhou 341100,China)

机构地区：[1]赣县区人民医院儿科,341100

出　　处：《中国现代药物应用》2023年第22期115-118,共4页Chinese Journal of Modern Drug Application

基　　金：江西省中医药管理局科技计划(项目编号:2022B572)。

摘　　要：目的探究保和丸联合阿莫西林克拉维酸钾治疗小儿肠系膜淋巴结炎(ML)的临床疗效。方法80例小儿肠系膜淋巴结炎患儿,随机分为对照组与观察组,每组40例。对照组给予阿莫西林克拉维酸钾治疗,观察组则在对照组基础上给予保和丸治疗。比较两组患儿西医疗效,中医疗效,腹痛缓解时间、腹痛消失时间,治疗前后肿大淋巴结数目及横径、纵径,不良反应发生情况。结果治疗7 d后,观察组患儿西医总有效率90.00%高于对照组的67.50%,差异具有统计学意义(P<0.05)。治疗7 d后,观察组中医总有效率95.00%显著高于对照组的72.50%,差异具有统计学意义(P<0.05)。观察组患儿腹痛缓解时间及腹痛消失时间分别为(3.75±0.63)、(6.72±1.22)d,均短于对照组的(4.94±0.87)、(7.83±2.06)d,差异具有统计学意义(P<0.05)。治疗前,两组患儿肿大肠系膜淋巴结数目及横径、纵径比较,差异均无统计学意义(P>0.05)。治疗7 d后,两组患儿肿大肠系膜淋巴结横径、纵径均明显短于治疗前,肿大淋巴结数目少于治疗前,且观察组患儿肿大肠系膜淋巴结横径、纵径均明显短于对照组,肿大淋巴结数目少于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为10.0%(4/40),对照组不良反应发生率为12.5%(5/40),两组患儿不良反应发生率比较差异无统计学意义(χ^(2)=0.125,P=0.723>0.05)。结论保和丸联合阿莫西林克拉维酸钾治疗小儿肠系膜淋巴结炎能提高患儿临床疗效,有效改善相关临床症状、体征,降低复发率,且安全性良好。Objective To investigate the clinical efficacy of Baohe pills combined with amoxicillin and clavulanate potassium in the treatment of children with mesenteric lymphadenitis(ML).Methods A total of 80 children with mesenteric lymphadenitis were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with amoxicillin and clavulanate potassium,while the observation group was treated with Baohe pills.Both groups were compared in terms of efficacy of Western medicine,efficacy of traditional Chinese medicine,remission time of abdominal pain,disappearance time of abdominal pain,the number,transverse diameter and longitudinal diameter of enlarged lymph nodes before and after treatment,and the occurrence of adverse reactions.Results After 7 d of treatment,the total effective rate of Western medicine in the observation group was 90.00%,which was higher than that of 67.50%in the control group,and the difference was statistically significant(P<0.05).After 7 d of treatment,the total effective rate of traditional Chinese medicine was 95.00%in the observation group,which was significantly higher than that of 72.50%in the control group,and the difference was statistically significant(P<0.05).The remission time of abdominal pain and disappearance time of abdominal pain in the observation group were(3.75±0.63)and(6.72±1.22)d,which were shorter than those of(4.94±0.87)and(7.83±2.06)d in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the number,transverse diameter and longitudinal diameter of enlarged lymph nodes between the two groups(P>0.05).After 7 d of treatment,the transverse diameter and longitudinal diameter of enlarged lymph nodes in both groups were significantly shorter than those before treatment in this group,and the number of enlarged lymph nodes was less than that before treatment in this group;the transverse diameter and longitudinal diameter of enlarge

关 键 词：保和丸 小儿肠系膜淋巴结炎 阿莫西林克拉维酸钾 腹痛 

分 类 号：R725.7[医药卫生—儿科]