细菌样颗粒-乳酸菌表面展示技术在黏膜疫苗中的应用  

Application of Bacterial-like Particles-surface Display Technology of Lactic Acid Bacteria in Mucosal Vaccine

作　　者：乔海英 李梦曼 胡念之 谭成成 王伟霞 孙丽敏 李信涛[1] 张鹏举[1] QIAO Haiying;LI Mengman;HU Nianzhi;TAN Chengcheng;WANG Weixia;SUN Limin;LI Xintao;ZHANG Pengju(Institute of Animal Husbandry and Veterinary Medicine,Jilin Academy of Agricultural Sciences,Changchun Jilin 130000,China;Science and Technology Exchange and Cooperation Office,Jilin Academy of Agricultural Sciences,Changchun Jilin 130000,China)

机构地区：[1]吉林省农业科学院畜牧兽医研究所,吉林长春130000 [2]吉林省农业科学院科技交流合作处,吉林长春130000

出　　处：《现代畜牧科技》2023年第12期115-118,共4页Modern Animal Husbandry Science & Technology

摘　　要：细菌样颗粒(Bacterium-like particles,BLP)是一种无生命的球形颗粒,直径为1~2μm,主要由肽聚糖(PGN)外表面组成。这些颗粒可以通过具有高亲和力和高负载能力的PA与外源性抗原结合,形成空心表面展示颗粒。BLP表面展示系统作为一种安全、有效、廉价、多功能的蛋白抗原负载平台被广泛应用于黏膜佐剂和黏膜疫苗的开发。该文对BLP的构建、优势及在黏膜疫苗上的应用进行综述。Bacteria-like particles(BLP)are nonliving spherical particles with a diameter of 1~2μm,mainly composed of peptidoglycan(PGN)outer surface.These particles can bind to exogenous antigens by PA with high affinity and high loading capacity to form hollow surface display particles.BLP surface display system,as a safe,effective,inexpensive and multifunctional protein antigen loading platform,has been widely used in the development of mucosal adjuvant and mucosal vaccine.This article reviewed the construction,advantages and application of BLP in mucosal vaccine.

关 键 词：细菌样颗粒 表面展示技术 疫苗 

分 类 号：Q93[生物学—微生物学]