健脾止泻汤联合复方嗜酸乳杆菌片治疗小儿腹泻的临床疗效  

Clinical efficacy of Jianpi Zhixie decoction combined with compound lactobacillus acidophilus tablets in the treatment of infantile diarrhea

作　　者：刘颖 谢艳丽 陈丹 朱贞 LIU Ying;XIE Yanli;CHEN Dan;ZHU Zhen(Department of Pediatrics,Ruijin Maternal and Child Health Hospital,Ruijin,Jiangxi,342500,China)

机构地区：[1]瑞金市妇幼保健院儿科,江西瑞金342500

出　　处：《当代医学》2023年第15期19-23,共5页Contemporary Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2021ZSF742)。

摘　　要：目的探究健脾止泻汤联合复方嗜酸乳杆菌片治疗小儿腹泻的临床疗效。方法选取2020年3月至2022年3月本院收治的70例腹泻患儿作为研究对象,按照治疗方法不同分为对照组与观察组,每组35例。对照组给予复方嗜酸乳杆菌片治疗,观察组在对照组基础上联合健脾止泻汤治疗,比较两组症状消退时间、免疫指标(IgA、IgG、CD4+/CD8+)、炎症因子[白细胞介素10(IL-10)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平、肠道屏障功能指标[二胺氧化酶(DAO)、D-乳酸]及临床疗效。结果治疗后,观察组呕吐、发热、腹痛消失时间及脱水纠正时间、大便性状恢复时间均明显短于对照组,差异有统计学意义(P<0.05)。治疗前,两组IgA、IgG、CD4+/CD8+比较差异无统计意义;治疗后,两组IgA、IgG、CD4+/CD8+均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-10、TNF-α和hs-CRP水平比较差异无统计意义;治疗后,两组IL-10水平均高于治疗前,TNF-α和hs-CRP水平均低于治疗前,且观察组IL-10水平高于对照组,TNF-α和hs-CRP水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组DAO、D-乳酸水平比较差异无统计意义;治疗后,两组DAO、D-乳酸水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.29%,明显高于对照组的77.14%,差异有统计学意义(P<0.05)。结论健脾止泻汤联合复方嗜酸乳杆菌片治疗小儿腹泻疗效显著,可有效缩短患儿症状消退时间,抑制机体炎症扩散,提升机体免疫力,调节肠道屏障功能,值得临床推广应用。Objective To explore the clinical efficacy of Jianpi Zhixie decoction combined with compound lactobacillus acidophilus tablets in the treatment of infantile diarrhea.Methods 70 children with diarrhea admitted to our hospital from March 2020 to March 2022 were selected as the research subjects,and they were divided into the control group and the observation group according to different treatment methods,with 35 cases in each group.The control group was treated with compound lactobacillus acidophilus tablets,while the observation group was treated with Jianpi Zhixie decoction on the basis of the control group,the symptom regression time,immune indexes(IgA,IgG,CD4+/CD8+),inflammatory factors(interleukin-10[IL-10],tumor necrosis factor-α[TNF-α],high-sensitivity C-reactive protein[hs-CRP]),intestinal barrier function indexes(diamine oxidase[DAO],D-lactic acid)and clinical efficacy were compared between the two groups.Results After treatment,the disappearance time of vomiting,fever,abdominal pain,dehydration correction time and stool recovery time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in IgA,IgG and CD4+/CD8+between the two groups;after treatment,the IgA,IgG and CD4+/CD8+of the two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of IL-10,TNF-αand hs-CRP between the two groups;after treatment,the levels of IL-10 of the two groups were higher than before treatment,and the levels of TNF-αand hs-CRP were lower than before treatment,and the levels of IL-10 in the observation group was higher than that in the control group,while the levels of TNF-αand hs-CRP were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no

关 键 词：健脾止泻汤 复方嗜酸乳杆菌片 小儿腹泻 免疫功能 炎症因子 

分 类 号：R725.7[医药卫生—儿科]