核苷类抗病毒药物治疗慢性乙型肝炎的疗效及对患者血清丙氨酸氨基转移酶水平的影响  

Efficacy of nucleoside antiviral drugs in the treatment of chronic hepatitis B and its effect on serum alanine aminotransferase levels in patients with chronic hepatitis B

作　　者：刘姝 郎华 鞠李 LIU Shu;LANG Hua;JU Li(Department of Laboratory,the Second Affiliated Hospital of Shenyang Medical College,Fushun,Liaoning,110000,China)

机构地区：[1]沈阳医学院附属第二医院检验科,辽宁抚顺110000

出　　处：《当代医学》2023年第15期152-155,共4页Contemporary Medicine

摘　　要：目的探讨核苷类抗病毒药物治疗慢性乙型肝炎的疗效及对患者血清丙氨酸氨基转移酶(ALT)水平的影响。方法选取2019年4月至2020年4月本院收治的86例慢性乙型肝炎患者作为研究对象,采取随机数字表法分为两组,每组43例。对照组采取常规治疗,观察组在对照组基础上应用核苷类抗病毒药物治疗,比较两组近期疗效、乙型病毒性肝炎病毒核酸(HBV-DNA)转阴率、乙型病毒性肝炎e抗原(HBeAg)转阴率及治疗前后血清白蛋白(ALB)、ALT、天冬氨酸氨基转移酶(AST)水平。结果观察组治疗总有效率为93.02%,明显高于对照组的74.42%,差异有统计学意义(P<0.05);观察组患者的HBV-DNA转阴率、HBeAg转阴率分别为55.81%、48.84%,均明显高于对照组的32.56%、27.91%,差异有统计学意义(P<0.05);治疗后,两组AST、ALT水平均低于治疗前,ALB水平均高于治疗前,且观察组AST、ALT水平均低于对照组,ALB水平高于对照组,差异有统计学意义(P<0.05)。结论核苷类抗病毒药物治疗慢性乙型肝炎疗效显著,可改善患者肝功能,且检测血清ALT水平可作为临床疗效评估的参考依据。Objective To investigate the efficacy of nucleoside antiviral drugs in the treatment of chronic hepatitis B and its effect on serum alanine aminotransferase(ALT)levels in patients with chronic hepatitis B.Methods A total of 86 patients with chronic hepatitis B admitted to our hospital from April 2019 to April 2020 were selected as the study subjects,they were randomly divided into two groups using the digital table method,with 43 patients in each group.The control group was treated with conventional therapy,while the observation group was treated with nucleoside antiviral drugs on the basis of the control group,the short-term efficacy,hepatitis B virus nucleic acid(HBV-DNA)negative conversion rate,hepatitis B e antigen(HBeAg)negative conversion rate,and serum albumin(ALB),ALT,and aspartate aminotransferase(AST)levels before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.02%,which was significantly higher than 74.42%in the control group,and the difference was statistically significant(P<0.05);the HBV-DNA negative conversion rate and HBeAg negative conversion rate in the observation group were 55.81%and 48.84%,respectively,which were significantly higher than 32.56%and 27.91%in the control group,and the differences were statistically significant(P<0.05);after treatment,the levels of AST and ALT in the two groups were lower than those before treatment,and the levels of ALB were higher than those before treatment,and the levels of AST and ALT in the observation group were lower than those in the control group,and the levels of ALB were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Nucleoside antiviral drugs are effective in the treatment of chronic hepatitis B,which can improve the liver function of patients,and the detection of serum ALT level can be used as the reference for clinical efficacy evaluation.

关 键 词：慢性乙型肝炎 转阴率 丙氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学]