左旋甲状腺素治疗亚临床甲状腺功能减退症的临床疗效及对甲状腺功能和血脂水平的影响  

Clinical efficacy of levothyroxine in the treatment of subclinical hypothyroidism and its effect on thyroid function and blood lipid levels

作　　者：曾蕊 ZENG Rui(Department of Occupational Diseases,the Second People's Hospital of Liaoyang,Liaoyang,Liaoning,111000,China)

机构地区：[1]辽阳市第二人民医院职业病科,辽宁辽阳111000

出　　处：《当代医学》2023年第15期155-157,共3页Contemporary Medicine

摘　　要：目的探讨左旋甲状腺素治疗亚临床甲状腺功能减退症(SH)的临床疗效及对甲状腺功能和血脂水平的影响。方法选取2017年1月至2020年1月本院收治的138例SH患者作为研究对象,按照随机数字表法分为对照组与研究组,每组69例。对照组给予常规治疗,研究组在对照组基础上给予左旋甲状腺素口服治疗,比较两组临床疗效、治疗前后甲状腺功能[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)]和血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)]水平。结果研究组治疗总有效率为91.30%,高于对照组的73.91%,差异有统计学意义(P<0.05)。治疗后,两组TSH水平均低于治疗前,FT3、FT4水平均高于治疗前,且研究组TSH水平低于对照组,FT3、FT4水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组TC、TG、LDL-C水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论左旋甲状腺素治疗SH患者疗效显著,下调机体TC、TG、LDL-C水平,改善患者甲状腺功能,值得临床推广应用。Objective To investigate the clinical efficacy of levothyroxine in the treatment of subclinical hypothyroidism(SH)and effect on thyroid function and blood lipid levels.Methods 138 patients with SH admitted to our hospital from January 2017 to January 2020 were selected as the research subjects,and they were divided into the control group and the study group according to the random number table method,with 69 cases in each group.The control group was given routine treatment,and the study group was given levothyroxine oral treatment on the basis of the control group,the clinical efficacy,thyroid function(thyroid stimulating hormone[TSH],free triiodothyronine[FT3],free tetraiodothyronine[FT4])and blood lipid(total cholesterol[TC],triglyceride[TG],low-density lipoprotein cholesterol[LDL-C])levels before and after treatment were compared between the two groups.Results The total effective rate of the study group was 91.30%,which was higher than 73.91%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TSH in the two groups were lower than those before treatment,the levels of FT3 and FT4 were higher than those before treatment,and the level of TSH in the study group was lower than that in the control group,the levels of FT3 and FT4 were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TC,TG and LDL-C in the two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Levothyroxine is effective in the treatment of SH patients,which can down-regulate the levels of TC,TG and LDL-C and improve the thyroid function of patients,which is worthy of clinical promotion and application.

关 键 词：亚临床甲状腺功能减退症 左旋甲状腺素 甲状腺功能 血脂 

分 类 号：R581.2[医药卫生—内分泌]