考察注射用利福平配置过程产生微粒的影响因素  

The influencing factors of particle formation during the configuration of rifampicin for injection were investigated

作　　者：黄华英[1] 叶小金 刘丽秀 钟洪兰[1] 招子聪[1] HUANAG Huaying;YE Xiaojing;LIU Lixiu;ZHONG Honglan;ZHAO Zicong(Guangzhou Chest Hospital,Guangzhou Key Laboratory of Tuberculosis Research,Guangdong Guangzhou 510095,China)

机构地区：[1]广州市胸科医院//广州市结核病研究重点实验室,广东广州510095

出　　处：《现代医院》2023年第12期1965-1968,共4页Modern Hospitals

基　　金：广东省医学科学技术研究基金(A2022025);广州市医学重点学科(2021-2023)结核病学;广州市科技计划项目(广州市科技市校(院)企联合资助项目(2023A03J0539))。

摘　　要：目的对注射用利福平在不同配置和使用条件下的输液微粒及PH值变化进行考察,为注射用利福平提供最佳的配置方法和最佳的输液质量控制策略。方法考察和检测不同配置和使用条件下注射用利福平的微粒数和pH值,分析影响注射用利福平在配置和使用过程影响微粒产生的因素。结果注射用利福平的稳定pH值为7.2~8.1,在遮光过滤、5%葡萄糖500 mL中微粒最少,配置后1~4 h时间内记录的微粒数最少。结论注射用利福平在配置和使用期间以遮光过滤、溶媒5%葡萄糖500 mL、配置后在1~4 h内使用,使用时用一次性精密过滤输液器为最佳的输液质量控制策略。Objective To investigate the change of infusion particles and PH value of rifampicin for injection under different configuration and application conditions,and to provide the best configuration method and the best infusion quality control strategy for rifampicin for injection.Methods The particle number and PH value of rifampin for injection were investigated and measured under different configuration and application conditions,and the factors affecting the formation of particles were analyzed.Results The stable pH value of Rifampicin for injection was 7.2-8.1,and the number of particles was the least in the light filtering and 5%glucose 500 mL,and the number of particles was the least in 1~4 h after the configuration.Conclusion The optimal infusion quality control strategy is to filter rifampicin for injection by blocking light,500 mL of solute 5%glucose,1~4 h after configuration,and use of disposable precision filter infusion set.

关 键 词：注射用利福平 稳定性试验 微粒 PH值 

分 类 号：R965.3[医药卫生—药理学]