血清可溶性肿瘤坏死因子相关凋亡诱导配体、半乳凝素3、摄食抑制因子-1与慢性阻塞性肺疾病合并抑郁的相关性分析  

Correlation analysis of serum soluble tumor necrosis factor-related apoptosis-inducing ligand,galectin-3,nesfatin-1,and chronic obstructive pulmonary disease complicated with depression

作　　者：张长洪[1] 张志华[1] 姬泽萱 ZHANG Changhong;ZHANG Zhihua;JI Zexuan(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou075000,China)

机构地区：[1]河北北方学院附属第一医院呼吸与危重症医学科,河北张家口075000

出　　处：《中国医药导报》2023年第29期116-120,共5页China Medical Herald

基　　金：河北省医学科学研究重点课题计划项目(20180868)。

摘　　要：目的探讨血清中可溶性肿瘤坏死因子相关凋亡诱导配体(s TRAIL)、半乳凝素3、摄食抑制因子-1与慢性阻塞性肺疾病(COPD)合并抑郁的相关性。方法选取2019年7月至2021年5月河北北方学院附属第一医院收治的COPD急性加重期住院患者173例,其中单纯COPD组103例,COPD合并抑郁组70例,记录并比较两组临床资料及血清s TRAIL、半乳凝素3、摄食抑制因子-1水平。采用logistic回归模型分析COPD合并抑郁的影响因素,进一步绘制受试者操作特征(ROC)曲线评估预测效能。结果COPD合并抑郁组COPD评估测试评分、治疗依从性差占比、合并慢性病占比、独居占比及血清s TRAIL、半乳凝素3、摄食抑制因子-1水平均高于单纯COPD组,第1秒用力呼气量占用力肺活量百分率(FEV_(1)/FVC)、第1秒用力呼气容积占预计值百分率(FEV_(1)pred)、职工医疗保险占比均低于单纯COPD组,差异有统计学意义(P<0.05)。多因素分析结果显示,FEV_(1)/FVC、FEV_(1)pred、治疗依从性、医疗保险类型及血清s TRAIL、半乳凝素3、摄食抑制因子-1均为COPD合并抑郁的影响因素(P<0.05)。ROC曲线分析结果显示,血清s TRAIL、半乳凝素3、摄食抑制因子-1三者单独及联合均对COPD合并抑郁有一定的预测价值(P<0.05)。结论COPD患者发生抑郁与多种因素有关,血清s TRAIL、半乳凝素3、摄食抑制因子-1联合检测对COPD患者合并抑郁诊断有一定价值。Objective To investigate the correlation of serum soluble tumor necrosis factor-associated apoptosis-inducing ligand(sTRAIL),galectin-3,nesfatin-1 with chronic obstructive pulmonary disease(COPD)complicated with depression.Methods A total of 173 hospitalized patients with acute exacerbation of COPD admitted to the First Affiliated Hospital of Hebei North University from July 2019 to May 2021 were selected,including 103 patients in the simple COPD group and 70 patients in the COPD combined with depression group.Clinical data and serum levels of sTRAIL,galectin-3,and nesfatin-1 of the two groups were recorded and compared.Logistic regression model was used to analyze the influencing factors of COPD combined with depression,and receiver operating characteristic(ROC)curve was further drawn to evaluate the prediction efficiency.Results The COPD assessment test score,the proportion of poor treatment compliance,the proportion of chronic diseases,the proportion of patients living alone,and the serum levels of sTRAIL,galectin-3,and nesfatin-1 in the COPD combined with depression group were higher than those in the simple COPD group,the percentage of forced expiratory volume in first second to forced vital capacity(FEV_(1)/FVC),the percentage of forced expiratory volume in the first second to the expected value(FEV_(1)pred),and the proportion of employees medical insurance in the COPD combined with depression group were lower than those in the simple COPD group,and the differences were statistically significant(P<0.05).The results of multivariate analysis showed that FEV_(1)/FVC,FEV_(1)pred,treatment compliance,medical insurance type,and serum sTRAIL,galectin-3,and nesfatin-1 were the influencing factors of COPD combined with depression(P<0.05).ROC curve analysis showed that serum sTRAIL,galectin-3,and nesfatin-1 alone and in combination had certain predictive value for COPD complicated with depression(P<0.05).Conclusion Depression in patients with COPD is associated with a variety of factors,serum sTRAIL,galectin-3,and ne

关 键 词：慢性阻塞性肺疾病 抑郁 可溶性肿瘤坏死因子相关凋亡诱导配体 半乳凝素3 摄食抑制因子-1 

分 类 号：R563[医药卫生—呼吸系统]