基于双心理论分析于睿教授运用肝心和合法治疗冠心病合并失眠的用药规律  

Analysis of the medication rules of Professor Yu Rui treated coronary heart disease combined with insomnia by harmonizing liver and heart based on the theory of double heart

作　　者：李爽[1] 于睿 张欢[3] 梁健 于游[4] 李可大 张杰[6] 贺亮亮 LI Shuang;YU Rui;ZHANG Huan;LIANG Jian;YU You;LI Keda;ZHANG Jie;HE Liangliang(Graduate School,Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110847,China;Department of Science and Technology,Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110847,China;College of Nursing,Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110847,China;the Second Department of Cardiology,Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang110021,China;Institute of Traditional Chinese Medicine Standardization,Liaoning Academy of Traditional Chinese Medicine,Liaoning Province,Shenyang110033,China;Department of Traditional Chinese Medicine,the First Affiliated Hospital of China Medical University,Liaoning Province,Shenyang110001,China;Department of Emergency,Liaoning Provincial Armed Police Corps Hospital,Liaoning Province,Shenyang110034,China)

机构地区：[1]辽宁中医药大学研究生学院,辽宁沈阳110847 [2]辽宁中医药大学科技处,辽宁沈阳110847 [3]辽宁中医药大学护理学院,辽宁沈阳110847 [4]辽宁中医药大学附属第二医院心病二科,辽宁沈阳110021 [5]辽宁省中医药科学院中医药标准化研究所,辽宁沈阳110033 [6]中国医科大学附属第一医院中医科,辽宁沈阳110001 [7]武警辽宁省总队医院急诊科,辽宁沈阳110034

出　　处：《中国医药导报》2023年第28期4-8,共5页China Medical Herald

基　　金：国家自然科学基金面上项目(82274494);国家中医药管理局中医药古籍文献和特色技术传承专项项目(GZY-KJS-2020-026);辽宁省社会科学规划基金项目(L19DSH002)。

摘　　要：目的基于双心理论探讨于睿教授运用肝心和合法治疗冠心病合并失眠的用药规律。方法收集2021年8月至2023年2月辽宁中医药大学附属医院及沈阳天仁合一智慧中医(互联网)医院经于睿教授诊治的冠心病合并失眠患者的处方,应用中医传承计算平台V 3.0对中药数据进行频数、四气、五味、归经、关联规则及聚类分析,挖掘核心处方,探讨其用药规律。结果共纳入有效处方107首,使用中药197味,得出频数>40的中药11味,以理气药、安神药为主,兼以化痰、祛瘀等;四气以温性、寒性和平性药物为主;五味以苦、甘和辛味居多;归经以肝、脾、肺、心经为主;常用药物组合29组,整理后的107首处方可分为5个聚类。结论于睿教授基于双心理论以肝心和合法治疗冠心病合并失眠患者,并根据临床辨证随证加减。Objective To explore the medication rules of Professor Yu Rui treated coronary heart disease combined with insomnia by harmonizing liver and heart based on the theory of double heart.Methods The prescriptions of patients with coronary heart disease and insomnia treated by Professor Yu Rui in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and Shenyang Tianren Heyi Intelligent Traditional Chinese Medicine(Internet)Hospital from August 2021 to February 2023 were collected.The traditional Chinese medicine inheritance computing platform V 3.0 was used to perform frequency,four nature,five flavours of drugs,meridian,association rules,and cluster analysis of the traditional Chinese medicine data to excavate the core prescriptions,and the rules of medication were explored.Results A total of 107 effective prescriptions were included,197 Chinese medicine were used,and 11 Chinese medicine with frequency more than 40 were obtained,mainly for carminative formula,tranquillizing formula,and dissipating phlegm and eliminating blood stasis,etc.The four nature of drugs were mainly warm,cold,and calm drugs.The five flavours of drugs were bitter,sweet,and pungent.The main meridians were liver,spleen,lung,and heart meridians.There were 29 groups of common drug combinations,and 107 prescriptions could be divided into five clusters.Conclusion Professor Yu Rui treated coronary heart disease combined with insomnia with the method of harmonizing liver and heart based on the theory of double heart,and added or subtracted according to clinical syndrome differentiation.

关 键 词：冠心病 失眠 数据挖掘 用药规律 肝心和合 

分 类 号：R541[医药卫生—心血管疾病]