《医方类聚》治疗胃痞的用药规律研究  

Study on the medication rules of Categorized Collection of Medical Formulas in treatment of stomach stuffiness disease

作　　者：唐燚 王柏欣 李敏[1] 朱立[1] TANG Yi;WANG Baixin;LI Min;ZHU Li(Department of Spleen and Stomach Diseases,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing100700,China)

机构地区：[1]北京中医药大学东直门医院脾胃病科,北京100700

出　　处：《中国医药导报》2023年第30期12-17,共6页China Medical Herald

基　　金：国家中医药管理局全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号);中华医学会医学教育分会和中国高等教育学会医学教育专业委员会医学教育研究立项课题(2018B-N20020);北京中医药新奥奖励基金课题(2018-XAJLJJ-008)。

摘　　要：目的研究并总结《医方类聚》中收录方剂治疗胃痞的用药规律。方法应用Excel 2016、IBM SPSS Modeler18.0、IBM SPSS Statistics 25软件对《医方类聚》中“五脏门”“诸气门”“脾胃门”“胀满门”中治疗胃痞的方剂所包含的药物进行频次统计,观察其功效、四气、五味、归经分布及芳香类药物使用比例,对全部药物进行Apriori关联规则分析及网络化分析,对高频药物进行系统聚类分析。结果《医方类聚》筛选得到胃痞诊断的方剂426首,涉及药物207味,主要以理气药和补虚药治疗胃痞,其中理气药以陈皮、木香为主,补虚药以甘草、人参、白术为主;药物四气五味以辛、苦、温为主,归经以脾、胃、肺、肾经为主;芳香类药物占全部药物频次的39.53%;共得到15项二项关联规则,高频药物可聚为9类。结论在《医方类聚》中,理气补虚法是治疗胃痞的基本原则,并在此基础上兼用温里、化痰(湿)、消食等治法。Objective To study and summarize the medication rules of the prescription included in Categorized Collection of Medical Formulas for the treatment of stomach stuffiness disease.Methods Excel 2016,IBM SPSS Modeler 18.0,and IBM SPSS Statistics 25 were used to make statistics on the frequency of drugs contained in the prescriptions for treating stomach stuffiness disease in the“fivezang men”,“zhuqi men”,“piwei men”,and“zhangman men”in the Categorized Collection of Medical Formulas.The efficacy,four natures,five flavours,distribution of channel tropism and use proportion of aromatic drugs were observed.Apriori association rule analysis and network analysis were performed for all drugs,and systematic cluster analysis was performed for high-frequency drugs.Results Categorized Collection of Medical Formulas was screened 426 prescriptions for the diagnosis of stomach stuffiness disease,involving 207 kinds of drugs,mainly to regulating qi-flowing drugs and tonifying deficiency drugs to treat stomach stuffiness disease,of which regulating qi-flowing drugs mainly to Citri Reticulatae Pericarpium,Aucklandiae Radix,tonifying deficiency drugs mainly to Glycyrrhizae Radix Et Rhizoma,Ginseng Radix Et Rhizoma,Atractylodis Macrocephalae Rhizoma.The four nature and five flavour of drugs were mainly pungent,bitter,and warm,and the channel tropism of drugs were mainly spleen,stomach,lung,and kidney channels.Aromatic drugs accounted for 32.90%of the total drug frequency.A total of 15 binomial association rules were obtained,and high-frequency drugs could be grouped into nine categories.Conclusion In Categorized Collection of Medical Formulas,the method of regulating qi and tonifying deficiency is the basic principle of treating stomach stuffiness disease,and on this basis,the method of warming,eliminating phlegm(dampness)and eliminating food is used.

关 键 词：医方类聚 胃痞 数据挖掘 理气补虚 

分 类 号：R24[医药卫生—中医临床基础]