肺动脉高压与心肌电重塑的发生机制的研究进展  

Research progress on the mechanism of pulmonary hypertension and myocardial electrical remodeling

作　　者：覃思润 陈晨阳 曹宇[1] QIN Sirun;CHEN Chenyang;CAO Yu(Department of Cardiovascular Medicine,the Third Xiangya Hospital,Central South University,Hunan Province,Changsha410013,China)

机构地区：[1]中南大学湘雅三医院心内科,湖南长沙410013

出　　处：《中国医药导报》2023年第31期44-47,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82000300)。

摘　　要：肺动脉高压(PAH)系肺动脉压、肺血管阻力增高致使患者右心室衰竭(RVF)甚至死亡的一种疾病。RVF为PAH患者最常见死亡原因,大量研究表明,PAH患者RVF进程中涉及一系列心肌重塑,包括心脏结构重塑、机械重塑及心肌电重塑,而心肌电重塑为患者合并恶性心律失常及导致心源性猝死的重要原因。近年来有许多关于PAH的分子遗传学及细胞生物学研究,本文对其中所包含的上游病理生理学机制及心肌电重塑在PAH发病机制中的生物功能和作用作一综述,为PAH临床治疗提供新靶标。Pulmonary arterial hypertension(PAH)is a disease that increases pulmonary arterial pressure and pulmonary vascular resistance leading to right ventricular failure(RVF)or even death of patients.RVF is the most common cause of death in patients with PAH.A large number of studies have shown that the process of RVF in PAH patients involves a series of myocardial remodeling,including cardiac structural remodeling,mechanical remodeling,and myocardial electrical remodeling,and myocardial electrical remodeling is an important cause of patients with malignant arrhythmia and sudden cardiac death.In recent years,there have been many studies on the molecular genetics and cell biology of PAH.This article reviews the upstream pathophysiological mechanism and the biological function and role of myocardial electrical remodeling in the pathogenesis of PAH,so as to provide new targets for the clinical treatment of PAH.

关 键 词：肺动脉高压 心肌电重塑 发生机制 研究进展 

分 类 号：R541[医药卫生—心血管疾病]