两个厂家注射用盐酸万古霉素有效性和安全性及经济性的真实世界研究  

Real-world Study on the Efficacy,Safety and Economics of Vancomycin Hydrochloride for Injection from Two Manufacturers

作　　者：张海霞[1,2] 陈杏凯 梁培 刘金春[1,2] 李一辰 刘梦颖[1,2] 汪思亮 朱怀军[1,2] 葛卫红 ZHANG Haixia;CHEN Xingkai;LIANG Pei;LIU Jinchun;LI Yichen;LIU Mengying;WANG Siliang;ZHU Huaijun;GE Weihong(Department of Pharmacy,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Nanjing Clinical Pharmacy Center,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院药学部,南京210008 [2]南京临床药学中心,南京210008

出　　处：《医药导报》2023年第12期1850-1855,共6页Herald of Medicine

摘　　要：目的基于真实世界数据评价两个厂家注射用盐酸万古霉素疗效、安全性及经济性差异。方法回顾性分析2013年1月1日—2019年12月31日南京大学医学院附属鼓楼医院静脉使用不同厂家注射用盐酸万古霉素的病例共6757例,采用1:1倾向性评分法匹配5308例,依据所使用的万古霉素厂家不同,分为两组,其中A组2654例,B组2654例,比较两组万古霉素有效性、安全性差异,并采用成本-效果分析方法比较其经济性。结果A组与B组万古霉素临床治愈率、细菌清除率、不良反应发生率均差异无统计学意义(P>0.05);两组万古霉素人均费用、日均费用及人均抗菌药物费用差异有统计学意义(P<0.05),B组药品费用高于A组。结论两厂家注射用盐酸万古霉素的疗效、安全性具有一致性。Objective To evaluate the differences in efficacy,safety and economics of vancomycin hydrochloride for injection between two manufacturers based on real-world data.Methods A total of 6757 cases of intravenous use of vancomycin hydrochloride for injection from different manufacturers between January 1,2013 and December 31,2019 in the Affiliated Drum Tower Hospital of Nanjing University Medical School were retrospectively analyzed,and 5308 cases were matched by 1:1 propensity score method,including 2654 cases in the group A(domestic drug group)and 2654 cases in group B(the innovator drug group).The differences in efficacy and safety between the two groups were compared.Cost-effectiveness analysis was used to compare the drug economics of the two groups.Results There were no significant differences in clinical cure rate,bacterial clearance rate,and incidence of adverse events between the two groups(P>0.05).In terms of economics,the average cost of vancomycin per capita,average daily cost of vancomycin and average cost of antibiotics per capita were significantly different between the two groups(P<0.05),and the cost of group B was higher than that of group A.Conclusion The efficacy and safety of vancomycin hydrochloride for injection were consistent between the two manufacturers.

关 键 词：万古霉素 真实世界研究 一致性评价 倾向性评分匹配法 

分 类 号：R978.16[医药卫生—药品] R956[医药卫生—药学]