注射用奈达铂致90例严重不良反应报告分析  

Analysis of 90 Cases of Serious Adverse Reactions Induced by Nedaplatin for Injection

作　　者：唐芳 邹舒鹏 张锦文[1] 陈云舟 TANG Fang;ZOU Shupeng;ZHANG Jinwen;CHEN Yunzhou(Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2023年第12期1879-1882,共4页Herald of Medicine

摘　　要：目的针对临床用药合理性以及应对严重不良反应策略展开探讨,分析注射用奈达铂致严重不良反应报告。方法收集华中科技大学同济医学院附属同济医院2012年1月至2021年12月上报至国家不良反应监测中心所有药品的严重不良反应,并对其关于奈达铂的90例严重不良反应进行回顾性分析。结果严重不良反应的发生与性别无关。在单用奈达铂发生严重不良反应(SADR)的患者中,首次使用奈达铂严重不良反应的发生率较高(占74.3%),不良反应发生时间以30 min内以及2~14 d内发生率最高,分别为呼吸困难、过敏性休克等严重过敏反应(34.4%)和Ⅱ至Ⅳ度骨髓抑制(51.2%),临床处理不良反应常以停药和对症治疗作为首选。结论在应用奈达铂作为化疗方案的同时,特别是首次使用的患者,应密切关注30 min内的过敏反应以及2周的骨髓抑制发生,做好抢救应急预案和定期检查血常规,防止严重不良反应的发生。Objective In order to discuss the rationality of clinical use of medication and the strategies of serious adverse reactions(SADR),the reports of SADRs caused by nedaplatin for injection were summarized and analyzed.Methods Methods Serious adverse reactions to all medicines reported to the National Adverse Reaction Monitoring Centre(NARMC)in Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology from January 2012 to December 2021 were collected,and a retrospective analysis of 90 patients among those cases with SADR after nedaplatin injection was carried out.Results The occurrence of SADRs was not related to the gender.In monotherapy with nedaplatin,the rate of serious adverse effects was high with the first use of nedaplatin(74.3%).The incidence of adverse reactions was highest within 30 minutes and 2-14 days,including severe allergic reaction(34.4%)and gradeⅡ-Ⅳmyelosuppression(51.2%),respectively.Drug withdrawal and symptomatic treatment were often the preferred treatment methods in clinical practice.Conclusion While using nedaplatin as a chemotherapy regimen,especially for the first time,patients should be closely monitored for the occurrence of severe anaphylaxis within 30 minutes and severe bone marrow suppression within 2 weeks.A rescue emergency plan for resuscitation and regular checking of the hemogram should be made to prevent the occurrence of serious adverse reactions.

关 键 词：注射用奈达铂 严重不良反应 抗肿瘤药 药品不良反应 综合报告 

分 类 号：R979.19[医药卫生—药品] R969.3[医药卫生—药学]