复方黄柏液涂剂对肛周脓肿一次性根治术后创面愈合和炎症因子的影响  

Effect of Compound Huangbai Liquid Paint on wound healing and inflammatory factors after one-off radical surgery for perianal abscess

作　　者：丁二军 卢超 吴旸洋 刘艳 桂慧俐 DING Erjun;LU Chao;WU Yangyang;LIU Yan;GUI Huili(Department of Anorectal Medicine,Jiujiang Hospital of Traditional Chinese Medicine,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市中医医院肛肠科,江西九江332000

出　　处：《中国当代医药》2023年第35期41-44,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140395)。

摘　　要：目的探讨复方黄柏液涂剂对肛周脓肿一次性根治术后创面愈合和炎症因子的影响。方法选取2019年8月至2021年8月九江市中医医院收治的80例肛周脓肿一次性根治术患者作为研究对象,采用随机数字表法将其分为参照组(40例)和研究组(40例)。参照组采用地奥司明口服+高锰酸钾坐浴治疗,研究组在参照组的基础上联合复方黄柏液涂剂治疗。统计两组患者的创面愈合时间,比较两组患者治疗前及治疗14 d后的中医证候积分、血清纤维连接蛋白(FN)、肉芽组织中细胞因子CD68、血清白介素-6(IL-6)、白介素-1β(IL-1β)水平。结果研究组治疗14 d后的血清FN、肉芽组织中细胞因子CD68水平均高于参照组,研究组治疗14 d后的中医证候积分、IL-6、IL-1β水平均低于参照组,研究组的创面愈合时间短于参照组,差异有统计学意义(P<0.05)。结论复方黄柏液涂剂辅助常规疗法治疗肛周脓肿一次性根治术后患者的临床效果更佳,有利于控制临床症状,加快创面愈合,减轻炎症反应,提高临床治疗效果。Objective To investigate the effect of Compound Huangbai Liquid Paint on wound healing and inflammatory factors after one-off radical surgery for perianal abscess.Methods A total of 80 patients with perianal abscess treated in Jiujiang Hospital of Traditional Chinese Medicine from August 2019 to August 2021 were selected as the research objects.They were divided into the reference group(40 cases)and the study group(40 cases)by random number table method.The reference group was treated with oral Diosmin+Potassium Permanganate sitz bath,and the study group was treated with Compound Huangbai Liquid Paint on the basis of the reference group.The wound healing time of the two groups was counted,and the traditional Chinese medicine syndrome score,serum fibronectin(FN),cytokine CD68 in granulation tissue,serum interleukin-6(IL-6),and interleukin-1β(IL-1β)levels before treatment and 14 days after treatment were compared between the two groups.Results After 14 days of treatment,the levels of serum FN and cytokine CD68 in granulation tissue in the study group were higher than those in the reference group,the traditional Chinese medicine syndrome score,IL-6 and IL-1βlevels in the study group were lower than those in the reference group,and the wound healing time in the study group was shorter than that in the reference group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of Compound Huangbai Liquid Paint combined with conventional therapy in the treatment of perianal abscess after one-off radical resection is better,which is beneficial to control clinical symptoms,accelerate wound healing,reduce inflammatory reaction,and improve clinical treatment effect.

关 键 词：复方黄柏液涂剂 地奥司明 高锰酸钾 肛周脓肿一次性根治术 创面愈合 炎症因子 

分 类 号：R657.1[医药卫生—外科学]