HbA1c、β2-MG、UACR与老年高血压血压变异性严重程度的关系  

Relationship between HbA1c,β2-MG,UACR and severity of blood pressure variability in elderly hypertensive patients

作　　者：徐艳玲 彭海燕 王琴 XU Yan-ling;PENG Hai-yan;WANG Qin(Department of Cardiology,Affiliated Hospital of Southwest Jiaotong University,Chengdu Third People's Hospital,Chengdu Institute of Cardiovascular Diseases,Chengdu Sichuan 610000,China)

机构地区：[1]西南交通大学附属医院/成都市第三人民医院心内科、成都市心血管病研究所,四川成都610000

出　　处：《临床和实验医学杂志》2023年第21期2269-2273,共5页Journal of Clinical and Experimental Medicine

基　　金：四川省科技计划项目(编号:2023YFS0298)。

摘　　要：目的探讨糖化血红蛋白(HbA1c)、β2-微球蛋白(β2-MG)、尿微量白蛋白/肌酐比值(UACR)与老年高血压患者血压变异性严重程度的关系。方法回顾性选取2019年4月至2022年9月成都市第三人民医院收治的167例原发性高血压患者作为高血压组、另外选取同期健康体检非高血压疾病志愿者80名作为对照组。对比两组研究对象的HbA1c、β2-MG、UACR、24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h平均收缩压变异率(24 h SBPV)、24 h平均舒张压变异率(24 h DBPV)、空腹血糖、餐后2 h血糖(2 h PG)、血肌酐、尿素氮、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。并根据高血压分级标准将高血压组分为不同等级进行分层分析(>2级患者121例,≤2级46例)。采用Pearson分析法分析HbA1c、β2-MG、UACR与血压变异性参数的关系。结果高血压组患者的HbA1c、β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、空腹血糖测定值均显著高于对照组,差异均有统计学意义(P<0.05);高血压组患者的24 h DBPV、2 h PG、血肌酐、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值与对照组比较,差异均无统计学意义(P>0.05)。>2级的原发性高血压患者的β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、血肌酐测定值均显著高于≤2级的原发性高血压患者,差异均有统计学意义(P<0.05);≤2级与>2级的原发性高血压患者的HbA1c、24 h DBPV、空腹血糖、2 h PG、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值比较,差异均无统计学意义(P>0.05)。原发性高血压患者β2-MG、UACR测定值与24 h SBPV、24 h DBPV均呈正相关(P<0.05)。结论原发性高血压患者的HbA1c、β2-MG、UACR高于非高血压患者,β2-MG、UACR测定值与原发性高血压患者的血压水平及血压变异性呈正相关。Objective To explore the relationship between hemoglobin A1c(HbA1c),β2-microglobulin(β2-MG),urinary microalbumin/creatinine ratio(UACR)and the severity of blood pressure variability in elderly hypertensive patients.Methods A total of 167 patients with primary hypertension admitted to Chengdu Third People's Hospital from April 2019 to September 2022 were retrospectively selected as the hypertension group,and 80 volunteers with non hypertensive diseases who underwent physical examinations during the same period were selected as the control group.The HbA1c,β2-MG,UACR,24 hour mean systolic blood pressure(24 h SBP),24-hour mean diastolic blood pressure(24 h DBP),24-hour mean systolic blood pressure variability(24 h SBPV),24-hour mean diastolic blood pressure variability(24 h DBPV),fasting blood glucose,postprandial 2-hour blood glucose(2 hPG),serum creatinine,urea nitrogen,triacylglycerol,total cholesterol,high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C).According to the hypertension grading standards,the hypertension components were divided into different levels for hierarchical analysis(121 patients with>2 levels and 46 patients with≤2 levels),and the relationship between HbA1c,β2-MG,UACR and blood pressure variability parameters was analyzed using Pearson analysis method.Results The measured values of HbA1c,β2-MG,UACR,24 h SBP,24 h DBP,24 h SBPV,and fasting blood glucose were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the 24 h DBPV,2 h PG,serum creatinine,urea nitrogen,triacylglycerol,total cholesterol,HDL-C,and LDL-C measurements between the hypertension group and the control group(P>0.05).The measured values ofβ2-MG,UACR,24 h SBP,24 h DBP,24 h SBPV,and serum creatinine were significantly higher in patients with≤grade 2 primary hypertension,and the differences were statistically significant(P<0.05).There were no statistically significant dif

关 键 词：糖化血红蛋白 Β2-微球蛋白 尿微量白蛋白 肌酐 老年 高血压 变异性 

分 类 号：R544.1[医药卫生—心血管疾病]