高原低氧诱导肠稳态失衡的分子机制及中药防治研究进展  

Molecular mechanism of high altitude hypoxia induced intestinal homeostasis imbalance and research progress of traditional Chinese medicine

作　　者：康倩 修明慧 张雪燕 杨丹[1,3] 王树威 和建政 龚红霞 曹旺杰[1,2,3] 苏韫 KANG Qian;XIU Minghui;ZHANG Xueyan;YANG Dan;WANG Shuwei;HE Jianzheng;GONG Hongxia;CAO Wangjie;SU Yun(Gansu University of Traditional Chinese Medicine,Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Province,Lanzhou 730000,Gansu,China;Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities,Lanzhou 730000,Gansu,China;Gansu Zhongshan University of Medicine,School of Basic Medicine,Lanzhou 730000,Gansu,China;Gansu University of Traditional Chinese Medicine,School of Public Health,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000 [2]甘肃中医药大学,敦煌医学与转化教育部重点实验室,甘肃兰州730000 [3]甘肃中医药大学,基础医学院,甘肃兰州730000 [4]甘肃中医药大学,公共卫生学院,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2023年第12期1391-1402,共12页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(82004228);甘肃省自然科学基金(21JR11RA144);2022年度甘肃省高等学校青年博士基金(2022QB-102);甘肃省中医药管理局项目(GZKP-2021-32)。

摘　　要：低氧是限制人群在高原生存的因素之一,能够引起呕吐腹泻、心慌气短、急性昏迷等症状。患有急性高原病的人约80%至少有一种胃肠道不适的症状,如厌食、恶心、腹泻、呕吐等。研究高原低氧所致肠损伤的病理特点、发病机制及药物防治,有利于高原胃肠道疾病的诊治。因此,本文通过总结相关文献,就高原低氧造成肠道损伤的相关研究进行系统阐述,对高原低氧造成肠道形态学、肠道细胞、肠道菌群等肠稳态的改变,引起肠道炎症、氧化损伤等机制及中药防治进行总结,以期为科研工作者和临床工作者提供借鉴及信息参考。Hypoxia is one of the factors restrict-ing the survival of people at high altitudes,which can cause various symptoms such as vomiting,diar-rhea,palpitations,shortness of breath and acute coma.About 80%of patients with acute mountain sickness have at least one symptom of a gastroin-testinal distress(e.g.,anorexia,nausea,diarrhea,vomiting,etc.).The pathological characteristics,pathogenesis and drug treatment of intestinal inju-ry caused by high-altitude hypoxia were studied,which is conducive to the diagnosis and treatment of plateau gastrointestinal diseases.Therefore,by summarized relevant literature and systematically expounds the related researches on intestinal dam-age caused by high altitude hypoxia.We summa-rized the changes of intestinal morphology,intesti-nal cells,intestinal flora and other intestinal ho-meostasis caused by high altitude hypoxia,the mechanism of intestinal inflammation and oxida-tive damage,and the treatment of traditional Chi-nese medicine,which provide reference and infor-mation for reference for scientific research workers and clinicians.

关 键 词：高原低氧 肠稳态失衡 抗缺氧 炎症 氧化损伤 

分 类 号：R965.2[医药卫生—药理学]