基于表面增强拉曼光谱的纳米纤维基生物传感器的研究进展  

Research progress in nanofiber-based biosensors based on surface enhanced Raman spectroscopy

作　　者：徐志豪 徐丹瑶 李彦 王璐[1,2] XU Zhihao;XU Danyao;LI Yan;WANG Lu(College of Textiles,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620

出　　处：《纺织学报》2023年第11期216-224,共9页Journal of Textile Research

基　　金：中央高校基本科研业务费专项资金资助项目(2232022G-01);高等学校学科创新引智计划项目(BP0719035)。

摘　　要：为促进纳米纤维基表面增强拉曼光谱(SERS)传感器在生物医用领域的开发及应用,介绍了纳米纤维基SERS基底的组成与性能评价指标,纳米纤维基底的构建方法及其性能影响因素。通过总结纳米纤维基SERS基底的构建方法,阐述了纳米纤维与等离子体材料原位组装和后组装的2种策略,进一步探究了纳米纤维种类及其形貌等对柔性SERS传感性能的影响机制。最后展示了纳米纤维基SERS基底在生物医用领域的应用,根据生物医用领域SERS传感器的性能要求对其未来发展趋势进行展望,以期为制备高性能的纳米纤维基柔性SERS基底及拓宽其实际应用提供一定参考。Significance Surface enhanced Raman spectroscopy(SERS)sensors are usually constructed from active elements and substrate materials,which have the advantages of simple operation and rapid monitoring.Electrospun nanofibers have unique three-dimensional curved channel,large specific surface area,high porosity and controllable stacking density.It not only provides a large number of sites for the loading of nanoparticles,but also facilitates the capture and transport of molecules to be tested,thereby enhancing SERS signals and improving detection sensitivity.Compared with the rigid detection substrate,the flexible substrate represented by electrospinning nanofibers can provide a more flexible detection process in complex environments,so it has great application potential.In order to promote the development and application of nanofiber-based SERS sensors in the biomedical field,it is important to explore the factors that affect the SERS sensing performance of nanofibers.Progress The composition and performance evaluation index of nanofiber-based SERS substrate,the construction method of nanofiber substrate,and its performance influencing factors are introduced.By summarizing the construction methods of nanofiber-based SERS substrates,two strategies of in-situ assembly and post-assembly of nanofibers and plasma materials are described.The SERS substrate prepared by in-situ assembly has good stability because most of the nanoparticles exist inside the fibers,but the detection sensitivity is slightly poor.The SERS substrate prepared by post-assembly is more easily combined with the molecule to be tested because the nanoparticles are distributed on the surface of the fiber,and the sensitivity is higher.The mechanism of the influence of the type and morphology of the nanofibers on the flexible SERS sensing performance was further explored.The difference in the hydrophilicity and hydrophobicity of the fibers and their morphology will affect the interaction with the nanoparticles and the molecules to be tested,thereby affecti

关 键 词：表面增强拉曼光谱 纳米纤维 静电纺丝 纳米颗粒 生物医用 生物传感器 

分 类 号：TS101.4[轻工技术与工程—纺织工程]