水溶性近红外染料泊洛沙姆-IR780的制备与表征  

Preparation and Characterization of Water-soluble Near-infrared Dye Poloxamer-IR780

作　　者：郭立强 朱志杰 陈思铭 张宇翾 GUO Liqiang;ZHU Zhijie;CHEN Siming;ZHANG Yuxuan(Jiangsu College of Engineering and Technology,Nantong 226007,China)

机构地区：[1]江苏工程职业技术学院,江苏南通226007

出　　处：《化工技术与开发》2023年第12期15-19,共5页Technology & Development of Chemical Industry

基　　金：南通市科技局项目(2021);江苏省大创项目(2021/7);校级科研项目(GYKY/2021/5)。

摘　　要：以医用材料泊洛沙姆127(Poloxamer F127)为原料,近红外染料IR 780为功能分子,用N,N’-羰基二咪唑分子活化泊洛沙姆分子的端羟基,在氮气保护的温和环境下,乙二胺与活化泊洛沙姆发生氨基化反应,最后在40℃下,以三乙胺为催化剂,氨基泊洛沙姆与IR 780(摩尔比为1∶3)反应36h,制备得到收率为76%的水溶性近红外新材料,通过红外光谱、氢谱对其结构进行了表征。性能测试发现,该结构物质水溶液的紫外吸收最大波长蓝移了110nm,佐证了泊洛沙姆-IR780的分子结构。Applied medical material Poloxamer 127(Poloxamer F127)as a raw material,the near-infrared dye IR780 as a functional molecule,N,N'-carbonyldiimidazole molecule was used to activate the terminal hydroxyl group of the poloxamer molecule in a mild environment protected by nitrogen.The amination reaction of ethylenediamine with activated poloxamer was carried out.The water-soluble near-infrared new material was prepared by the substitution reaction of active chlorine and aminohydrogen in IR780 structure,and its structure was characterized by infrared spectroscopy and hydrogen spectroscopy.The performance test found that the maximum absorption wavelength of the aqueous solution of the structural substance was 624 nm,and the blue shifted 110nm compared with IR780,also confirmed the molecular structure of the poloxamer-IR780.

关 键 词：近红外染料IR780 泊洛沙姆-IR780 水溶性染料 

分 类 号：TQ617.3[化学工程—精细化工]