血清CASP2表达与缺氧缺血性脑病患儿NBNA评分及预后的关系  

Relationship between serum CASP2 expression and NBNA score and prognosis in children with hypoxic-ischemic encephalopathy

作　　者：魏燕云 李艳民[1] WEI Yanyun;LI Yanmin(Department of Neonatology,Handan City First Hospital,Handan,Hebei 056002,China)

机构地区：[1]邯郸市第一医院新生儿科,河北邯郸056002

出　　处：《国际检验医学杂志》2023年第24期3006-3009,3015,共5页International Journal of Laboratory Medicine

基　　金：河北省2020年度医学科学研究课题(20200437)。

摘　　要：目的探讨缺氧缺血性脑病(HIE)患儿血清半胱氨酸天冬氨酸蛋白酶2(CASP2)水平与新生儿神经行为(NBNA)评分的相关性,以及CASP2在预后中的评估价值。方法选取2018年1月至2022年4月该院的114例HIE患儿为HIE组,根据患儿病情严重程度分为轻度组40例,中度组52例,重度组22例;根据治疗6个月后的预后情况将114例HIE患儿分为预后不良组26例和预后良好组88例。同期选择于该院出生的健康新生儿106例作为对照组。记录NBNA评分,采用酶联免疫吸附试验检测血清CASP2水平;采用Pearson相关分析HIE患儿血清CASP2水平与NBNA评分的相关性;采用受试者工作特征(ROC)曲线分析NBNA评分及血清CASP2水平对HIE患儿预后的预测价值。结果HIE组血清CASP2水平高于对照组,NBNA评分低于对照组(P<0.05)。重度组血清CASP2水平高于中度组、轻度组,NBNA评分低于中度组、轻度组(P<0.05);中度组血清CASP2水平高于轻度组,NBNA评分低于轻度组(P<0.05)。HIE患儿NBNA评分与血清CASP2水平呈负相关(r=-0.608,P<0.05)。预后不良组血清CASP2水平高于预后良好组,NBNA评分低于预后良好组(P<0.05)。血清CASP2水平及NBNA评分单独及联合预测HIE患儿预后不良的曲线下面积分别为0.875(95%CI 0.797~0.952)、0.748(95%CI 0.639~0.857)、0.927(95%CI 0.873~0.981)。结论血清CASP2水平随着HIE患儿病情严重程度增加而升高,且与患儿NBNA评分密切相关,有重要的预后预测价值。Objective To study the correlation between serum cysteine aspartate proteinase 2(CASP2)level and neonatal behavioral neurological assessment(NBNA)score in children with hypoxic-ischemic encephalopathy(HIE),and the value of CASP2 in evaluating prognosis.Methods A total of 114 neonates with HIE in this hospital from January 2018 to April 2022 were selected as HIE group.According to the severity of the disease,the neonates were divided into mild group(40 cases),moderate group(52 cases)and severe group(22 cases).According to the prognosis after 6 months of treatment,114 neonates with HIE were divided into poor prognosis group(26 cases)and good prognosis group(88 cases).At the same time,106 healthy neonates born in the hospital were selected as the control group.The NBNA score was recorded,and the serum CASP2 level was detected by enzyme-linked immunosorbent assay.Pearson correlation was used to analyze the correlation between serum CASP2 level and NBNA score in HIE children.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of NBNA score and serum CASP2 level for the prognosis of neonates with HIE.Results The level of serum CASP2 in HIE group was higher than that in control group,and the NBNA score was lower than that in control group(P<0.05).The level of serum CASP2 in the severe group was higher than that of the moderate group and mild group,and the NBNA score was lower than that of moderate group and mild group(P<0.05).The level of serum CASP2 in the moderate group was higher than that of the mild group,and the NBNA score was lower than that of the mild group(P<0.05).The NBNA score was negatively correlated with the serum level of CASP2 in the children with HIE(r=-0.608,P<0.05).The poor prognosis group had a significantly higher serum level of CASP2 and a significantly lower NBNA score than the good prognosis group(P<0.05).The serum level of CASP2 and NBNA score separate and joint area under the curve of the poor children with HIE prognosis were 0.875(95%CI 0.797-0.952),0.748(95%C

关 键 词：缺氧缺血性脑病 新生儿 半胱氨酸天冬氨酸蛋白酶-2 神经系统发育 

分 类 号：R722.1[医药卫生—儿科]