中老年男性人群高胆固醇血症与小肠细菌过度生长的关系探讨  

Association between hypercholesterolemia and small intestinal bacterial overgrowth in middle-aged and elderly men

作　　者：李佳[1,2] 唐帅 马金霞 朱文娅[1] 李毅 廖涵[1] 万军 LI Jia;TANG Shuai;MA Jinxia;ZHU Wenya;LI Yi;LIAO Han;WAN Jun(Department of Gastroenterology&National Clinical Research Center for Geriatric Diseases,the Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Gastroenterology,the 983rd Hospital of Joint Logistic Support Force of PLA,Tianjin 300142,China)

机构地区：[1]解放军总医院第二医学中心消化科&国家老年疾病临床医学研究中心,北京100853 [2]联勤保障部队第983医院消化科,天津300142

出　　处：《解放军医学院学报》2023年第9期956-960,978,共6页Academic Journal of Chinese PLA Medical School

基　　金：军委后勤保障部专项课题(17BJZ46)。

摘　　要：背景小肠细菌过度生长(small intestinal bacterial overgrowth,SIBO)是小肠的肠道菌群的病理性生长。近年来有研究发现高胆固醇血症伴随肠道菌群变化,但高胆固醇血症与SIBO的关系尚不明确。目的探讨中老年男性高胆固醇血症与SIBO的关系。方法纳入2018年10月-2019年10月在解放军总医院第二医学中心消化内科门诊就诊的年龄≥50岁男性患者,根据有/无SIBO分组,采用多因素Logistic回归模型,分析高胆固醇血症与SIBO患病的关系。结果237例受试者,年龄(73.28±10.03)岁,其中SIBO 166例(70.04%),高胆固醇血症50例(21.1%)。SIBO(+)组的高胆固醇血症和有胃肠切除术史的比例显著高于SIBO(-)组(P均<0.05)。多因素二元Logistic回归结果显示,在逐步调整了年龄、体质量指数、胃肠手术史、白蛋白、总蛋白、谷氨酰转肽酶等参数后发现,高胆固醇血症患者SIBO的患病概率是胆固醇正常者的2.397倍(95%CI:1.034~5.558)。结论消化科门诊非器质性消化道疾病的中老年男性人群中,高胆固醇血症与SIBO存在正向关联。Background Intestinal bacterial overgrowth(SIBO)is the pathological growth of the gut microbiota of the small intestine.Recent studies have shown that hypercholesterolemia is associated with alterations in gut microbiota.However,the association between hypercholesterolemia and SIBO is poorly understood.Objective To investigate the association between hypercholesterolemia and SIBO in middle-aged and elderly men.Methods Male patients aged≥50 years old who visited the Outpatient Department of Gastroenterology of the Second Medical Center of Chinese PLA General Hospital from October 2018 to October 2019 were enrolled.Subjects were divided into the SIBO(+)and SIBO(-)groups.Multivariate binary logistic regression model was used to evaluate the association between hypercholesterolemia and SIBO.Results A total of 237 subjects were enrolled,including 50 subjects with hypercholesterolemia(prevalence 21.1%)and 166 subjects with SIBO(prevalence 70.04%).The proportion of hypercholesterolemia and history of gastroenterectomy in SIBO(+)group was higher than that in SIBO(-)group(P<0.05).Multivariate logistic regression showed that after adjusting for age,BMI,history of gastrointestinal surgery,and serum levels of albumin,total protein and glutamyl transpeptidase,the incidence of SIBO in patients with hypercholesterolemia was 2.397 times of that in those with normal cholesterol(95%CI:1.034-5.558).Conclusion Hypercholesterolemia is positively associated with SIBO in middle-aged and elderly men with non-organic gastrointestinal disease in the outpatient department of gastroenterology.

关 键 词：小肠细菌过度生长 高胆固醇血症 肠道菌群 老年男性 消化疾病 

分 类 号：R589.2[医药卫生—内分泌]