液质联用技术在化妆品抗感染类药物检测中的应用  

Application of liquid chromatography-mass spectrometry in the detection of anti-infective drugs in cosmetics

作　　者：胡贝 李丽霞 丁晓萍 吕稳 李晓健 李琼 Bei Hu;Lixia Li;Xiaoping Ding;Wen Lv;Xiaojian Li;Qiong Li(Hubei Institute for Drug Control,Wuhan,Hubei 430075,China;Hubei Engineering Research Center for Drug Quality Control,Wuhan,Hubei 430075,China)

机构地区：[1]湖北省药品监督检验研究院,湖北武汉430075 [2]湖北省药品质量检测与控制工程技术研究中心,湖北武汉430075

出　　处：《日用化学工业（中英文）》2023年第12期1443-1450,共8页China Surfactant Detergent & Cosmetics

基　　金：湖北省药品监督检验研究院中青年科研项目(2022YN002)。

摘　　要：概述了化妆品中添加抗感染类药物的作用及对人体的安全风险,液质联用技术常用的质量分析器种类、特点及应用领域。介绍了《化妆品安全技术规范》(2015年版)中化妆品抗感染类药物的检测方法,并列出了国内外文献报道的应用液相色谱-三重四极杆串联质谱、实时直接分析-高分辨质谱、超高效液相色谱-四极杆/静电场轨道阱高分辨质谱、超高效液相色谱-线性离子阱/静电场轨道阱高分辨质谱和超高效液相色谱-四极杆-飞行时间高分辨质谱检测抗感染类药物的情况,并包含了《化妆品安全技术规范》(2015年版)中尚无检测方法的三种物质,分别是丹诺沙星、甲氧苄啶和洛硝达唑。本文可以为行业相关科研人员提供参考资料,为相关检验检测机构的高效筛查和风险监测提供方向,为标准检测方法的制修订提供科学依据。最后对化妆品中抗感染类药物的检测方法的开发趋势进行了介绍。The effects and safety risks of adding anti-infective drugs in cosmetics were summarized.The common types,characteristics and application fields of liquid chromatography-mass spectrometry were introduced.The methods in“Safety and Technical Standards for Cosmetics(2015 Edition)”for determination of anti-infective drugs were also listed in this paper.The advantages of various detection methods were introduced,including liquid chromatography triple quadrupole tandem mass spectrometry(LC-MS/MS),direct real-time analysis-high resolution mass spectrometry(DART-Q-Exactive-Orbitrap-MS),ultra-performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q-Orbitrap MS),ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry(UPLC-LTQ/orbitrap MS)and ultra high performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry(UPLC-Q-TOF-MS).In the sample screening process,some scholars detected three compounds that had not yet been detected in the“Safety and Technical Standards for Cosmetics(2015 Edition)”,namely danofloxacin,trimethoprim and ronidazole.This paper can provide data for the relevant scientific research work in cosmetics.At the same time,the risk monitoring work of cosmetics in relevant testing institution will have direction and ideas after understanding the above content.In addition,the exploratory research on the correction of detection method will be more efficient and scientific.Finally,the trend of using liquid chromatography-mass spectrometry to establish methods for determination of anti-infective drugs in cosmetics is recommended.Liquid chromatography-mass spectrometry is still the preferred method for the determination of antiinfective drugs in cosmetics in the future.Above all,high resolution mass spectrometry will be more widely used in the confirmation of known substances and screening of unknown substances.

关 键 词：液质联用技术 化妆品 抗感染类药物 检测方法 

分 类 号：TQ658[化学工程—精细化工]