复方丹参滴丸联合氯吡格雷片对老年冠心病冠脉内介入术后心绞痛患者的治疗效果  

Therapeutic effect of compound Danshen dripping pills combined with clopidogrel tablets on patients with angina pectoris after percutaneous coronary intervention for coronary heart disease

作　　者：李劲松 田茂[1] 刘晓楚 王斌[1] 汪宇 LI Jin-song;TIAN Mao;LIU Xiao-chu;WANG Bin;WANG Yu(Department of Cardiovascular Medicine,Luzhou People s Hospital,Luzhou 646000,Sichuan,China)

机构地区：[1]泸州市人民医院心血管内科,四川泸州646000

出　　处：《川北医学院学报》2023年第12期1603-1607,共5页Journal of North Sichuan Medical College

基　　金：四川省科技创新苗子工程资助项目(2022099)。

摘　　要：目的:探索复方丹参滴丸联合氯吡格雷片对老年冠心病冠脉内介入术后心绞痛患者的治疗效果。方法:选取110例老年冠心病PCI术后心绞痛患者作为研究对象,按照治疗方式不同将患者分为联合组(复方丹参滴丸联合氯吡格雷片治疗)和对照组(常规治疗+氯吡格雷片治疗)。比较两组疗效、心绞痛发作情况、心肌酶、血液流变学指标、血管内皮功能指标、LPa、ApoA1、ApoB水平和不良反应发生情况。结果:与对照组比较,联合组治疗总有效率更高,心绞痛发作次数和发作持续时间更低;治疗后,两组CK、LDH和CK-MB、BV高切、PV和BV低切、ET-1、LPa、apoB水平均降低,且联合组低于对照组(P<0.05);FMD、NO和apoA1水平均升高,且联合组高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方丹参滴丸联合氯吡格雷片治疗PCI术后心绞痛疗效确切,能有效缓解患者心绞痛症状,改善血液流变,调节血管内皮和脂代谢水平,安全性良好,值得应用。Objective:To analyze the therapeutic effect of compound Danshen dripping pills combined with clopidogrel tablets on elderly patients with angina pectoris after percutaneous coronary intervention(PCI)for coronary heart disease.Methods:110 elderly patients with angina pectoris after PCI for coronary heart disease were selected and divided into control group(conventional treatment^(+)clopidogrel tablets)and combined group(compound Danshen dripping pills on the basis of control group)according to the different treatment methods.The efficacy,angina pectoris attacks,myocardial enzymes,hemorheological indicators,vascular endothelial function indicators,LPa,ApoA1 and ApoB and occurrence of adverse reactions were compared between the two groups.Results:Compared with the control group,the combined group had a higher total effective rate,and lower frequency and duration of angina pectoris attacks.After treatment,levels of CK,LDH and CK-MB,BV high-shear,PV and BV low-shear,ET-1,LPa,and apoB in both groups decreased,and the combined group was lower than the control group(P<0.05).The levels of FMD,NO and apoA1 increased,and the combined group was higher than the control group(P<0.05).There were no significant differences in the adverse reactions between both groups(P>0.05).Conclusion:Compound Danshen dripping pills combined with clopidogrel tablets has a definite efficacy in the treatment of angina pectoris after PCI,and it can effectively relieve the symptoms of angina pectoris,improve the hemorheology,and regulate the vascular endothelium and lipid metabolism,and it has good safety and is worthy of application.

关 键 词：复方丹参滴丸 氯吡格雷片 冠心病冠脉内介入术 心绞痛 心肌酶 

分 类 号：R541.4[医药卫生—心血管疾病]