HMGB1调控IL-17分泌与中性粒细胞性哮喘的研究进展  

Research progress of HMGB1 regulates IL-17 secretion in neutrophilic asthma

作　　者：王慧虹 张秀峰 WANG Huihong;ZHANG Xiufeng(The Second Affiliated Hospital of Hainan Medical University,Haikou 570145,Hainan,China)

机构地区：[1]海南医学院第二附属医院,海南海口570145

出　　处：《中南医学科学杂志》2023年第6期978-981,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金项目(81960006)。

摘　　要：哮喘是一种慢性炎症性疾病,根据不同炎症细胞类型分为Th2型和非Th2型。非Th2型哮喘的特征是类固醇激素抵抗,以中性粒细胞性哮喘为主。高迁移率族蛋白1(HMGB1)是一种属于警报素家族的染色质结合蛋白,作为促炎介质参与急性和慢性免疫疾病的发生发展,是非Th2型哮喘生物标志物。本文综述HMGB1调控IL-17分泌与中性粒细胞性哮喘的关系。Asthma is a chronic inflammatory disease,dividing into Th2 and non-Th2 types according to different inflammatory cell types.Non-Th2 asthma is characterized by steroid hormone resistance and dominated by neutrophilic asthma.High mobility group box 1(HMGB1)is a chromatin binding protein belonging to the alertin family,which is involved in the occurrence and development of acute and chronic immune diseases as a pro-inflammatory mediator and a biomarker of non-Th2 asthma.This paper reviews the relationship between the regulation of IL-17 secretion by HMGB1 in neutrophilic asthma.

关 键 词：非Th2型哮喘 Th2型哮喘 类固醇激素抵抗 中性粒细胞性哮喘 HMGB1 IL-17 

分 类 号：R562.25[医药卫生—呼吸系统]